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Amanda Corbel

Manager, Communications Office

Email amanda.corbel@nih.gov or call 301-228-4489 for all media related questions.

Colored micrograph of HPV particles.
Cancer Genomics Research Laboratory

Different high-risk HPV infections don’t spur cancers at the same rate

 A study mapped the frequency at which different high-risk human papillomavirus (HPV) strains progress to cervical cancer and linked some strains to distinct genetic signatures, which could help scientists better understand these infections and open the door to targeted treatment approaches. The study published in Tumour Virus Research examined more than 700 cancer-free, precancer, early-stage cancer, and invasive cancer biopsy samples obtained from women in Guatemala who underwent screening or treatment in a hospital setting. Looking at a spectrum of precancer and cancer stages allowed the researchers to analyze trends between HPV strains and cancer progression. HPV is a common sexually transmitted infection. Most cases eventually get cleared by the immune system. However, women who have a lasting infection with any one of 15 high-risk strains can develop cervical cancer. These cancers are preventable and can be treated but still cause over 300,000 deaths worldwide each year, mainly in resource-limited POSTED: 4/2/2025
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Early-career period of depression builds resilience in top Frederick National Laboratory imaging scientist

 Depression upended his life when Kedar Narayan, Ph.D. was a graduate student and post doc, but he’s rarely talked about the experience and it’s likely most of his peers know nothing of his struggle. Now the imaging scientist at the Frederick National Laboratory for Cancer Research (FNL) is sharing his story broadly, in an interview on a special mental health episode of the Microscopists podcast. Narayan is group leader at the Center for Molecular Microscopy at FNL, which supports National Cancer Institute research. He revealed this period of depression as the most difficult time of his life during a previous appearance on the podcast, and host Peter O’Toole invited him to return for the mental health discussion. Narayan and O’Toole are joined on the podcast by Beth Cimini, Ph.D. who leads an imaging laboratory at the Broad Institute of the Massachusetts Institute of Technology and Harvard, and shares her story POSTED: 12/17/2024
Biotech Connector graphic and genomic map
Biotech Connector

Biotech Connector showcases advances in next-generation sequencing

The final Biotech Connector of 2024 focused on advances and uses of next-generation sequencing (NGS) by three organizations in the Frederick, Md, region. NGS can rapidly sequence DNA and RNA, enabling scientists to study genetic variation. It’s called “next generation” because it represents a substantial leap forward over older methods. NGS was first launched in 2000 but has been continually advanced since. The Biotech Connector is a quarterly networking and speaker series, hosted by the Frederick National Laboratory for Cancer Research and the Frederick County Chamber of Commerce, to bring together life science professionals for an inside look at local advances and to network. The advantages of NGS are “throughput, speed, and scale” explained Olena Lar, Ph.D., senior director of research and development at CIAN Diagnostics and one of the event’s three speakers. NGS achieves this by investigating millions of fragments of DNA or RNA simultaneously. Sequencing technologies Bao Tran POSTED: 12/4/2024
Illustration of mitochondria on sticks in a row
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