Image of original whole-slide image of liver tumor with annotation by pathologists, courtesy PAIP 2019.

FREDERICK, Md. – Frederick National Laboratory for Cancer Research’s medical imaging expertise received the highest rating at a recent grand challenge for pathology that featured nearly 1,000 competitors from around the world.

Tanja Grkovic inspects a 384 well plate containing natural product chemical fractions before it is shipped out for screening.

FREDERICK, Md. -- Tree bark, microbes, and mold are not simply the stuff you rake in the back yard and track in on the bottom of your shoes. They just might be a treatment for a rare disease. 

Products found in nature gave rise to some of our most familiar and relied-upon therapies including some antibiotics and decongestants and aspirin. There may be another treatment contained in a sea sponge or a leaf, but sifting through to isolate that compound is a complex undertaking. Scientists find natural products notoriously difficult to work with.

Stock image of stethoscope and medical papers.

Ethan Dmitrovsky: X Factor

Published: 11/21/2019Tagged:

"While medicine, like physics, uses probability to help solve its problems, only medicine includes the human element as a factor in its calculations."

A Janus G3 Automated Workstation at the Cancer Genomics Research Laboratory, one of the instruments used to conduct the TypeSeq assay.

FREDERICK, Md. -- Scientists at the Frederick National Laboratory for Cancer Research, the National Cancer Institute, and other collaborating institutions have demonstrated that their recently developed technique for detecting human papillomavirus (HPV) in patient samples performs comparably to existing gold-standard methods.

Biophysical Journal, The Premier Journal of Quantitative Biology, Volume 116, Number 6, March 19, 2019,, Biophysical Society, Cell Press

FREDERICK, Md. -- A study defining how an oncogenic protein gets removed from its active spot may offer new ways to target unwanted cell growth, a hallmark of cancer.

KRAS is a membrane-binding protein that functions as a molecular switch to regulate cellular activity, and is the most frequently mutated oncogene in human cancer. Normal KRAS controls cell growth. When KRAS is mutated, the signal is disrupted and cells grow continuously. 

Ulrich Baxa, senior microscopist at the National Cryo Electron Microscopy Facility, has seen the facility grow to house two additional microscopes, including the FEI Glacios (white-and-black cabinet, left of image).

FREDERICK, Md. -- Ulrich Baxa, Ph.D., and his team are helping to move a microscope the size of a minivan.

The behemoth, a Titan Krios, is making the 29-mile trek from a Gaithersburg, Maryland, laboratory to its new home at the Frederick National Laboratory for Cancer Research. It’s a highly-sensitive, $7 million device being relocated across a greater metropolitan area with some of the worst traffic in the United States.

University of Delaware campus

FREDERICK, Md. -- High-performance computing and other data science technologies are enabling critical inroads in cancer research. However, bringing together the necessary computing and cancer biology expertise to effectively leverage these technologies is a challenge—a challenge that a new partnership between the Frederick National Laboratory for Cancer Research and the University of Delaware is working to overcome. 

Ebola mAb114 vial

FREDERICK, Md. -- Just 48 hours after an Ebola clinical trial in the Democratic Republic of Congo (DRC) was stopped early because two therapies appeared to significantly reduce patients’ fatality rates, two Frederick National Laboratory staff members boarded a plane to help with the next step.

Meanwhile, the national laboratory’s Vaccine Clinical Materials Program (VCMP) sent a shipment of mAb114, one of the therapies, to the DRC.

Purdue University. Image by David Mark from Pixabay.

FREDERICK, Md. – Frederick National Laboratory for Cancer Research has launched a partnership with Purdue University that aims to enhance and accelerate research initiatives, technological innovation, and workforce development in the biomedical sciences.

FNL Chief Science Officer Leonard Freedman, Ph.D. gave the keynote presentation at the 15th anniversary of the Instituto Nacional de Medicina Genómica in Mexico City. Photo courtesy of INMEGEN.

MEXICO CITY -- An engagement between the Frederick National Laboratory for Cancer Research and the National Cancer Institute of Mexico (INCan) kicked off in July with a presentation about the FNL to a gathering of Mexican cancer researchers in Mexico City. 

FNL Chief Science Officer Leonard Freedman, Ph.D. highlighted some of the national laboratory’s key initiatives in a talk at a conference marking the 15thanniversary of the Instituto Nacional de Medicina Genómica (INMEGEN), one of Mexico’s 12 national institutes under the Secretariat of Health.