Some of the world’s top scientific leaders in the field will highlight the current progress of artificial intelligence...
A nanoparticle-based flu vaccine discovered and developed by the Vaccine Research Center, National Institute of Allergy...
An initiative at Frederick National Laboratory for Cancer Research (FNL) is confronting what’s been dubbed the...

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Second HIV patient appears to have cured herself with natural immunity

Basic Science Program, Mary Carrington, Ph.D.Posted 3/15/2022
Frederick National Laboratory scientists were part of a multi-institutional collaboration that has identified a second patient whose natural immune response to HIV infection appears to have cured her of the disease, raising the question: Can this be replicated? Only three other patients have ever been declared fully cured, but each of these outcomes was accomplished…

Cancer researchers invited to apply for new cryo-EM training program

National Cryo-Electron Microscopy Facility, NCEF Cryo-EM Training ProgramPosted 3/9/2022
The Frederick National Laboratory will host a new training program in Frederick, Maryland, September 12-16 for cancer researchers who want to build expertise in cryo-electron microscopy (cryo-EM). Cryo-EM is a microscopy technique where samples are flash-frozen and bombarded with electrons to generate images. The resulting high-resolution images are helping cancer…

Columbia University students employ AI to predict chemical properties in hands-on drug discovery project

Cancer Data Science Initiatives, Partnership Development OfficePosted 2/28/2022
Seven Columbia University graduate students recently completed drug discovery projects at the Frederick National Laboratory for Cancer Research (FNL) as part of their fall 2021 semester. Since 2020, 40 Columbia University students have completed projects with the FNL for their master’s degree coursework. The projects represent a partnership between Columbia University’s…

Lack of reaction to the COVID-19 shot doesn’t mean it’s not working as it should

Posted 2/23/2022
You may have had a sore arm, felt tired, or had a headache. Maybe you ran a slight fever. You might have heard these things happen because your COVID-19 shot is working as it should. On the other hand, a lack of side-effects does not point to vaccine failure, according to a new study. The relationship between a reaction to COVID-19 vaccines and the strength of antibody…

Team connects genetic variant to poor outcomes after certain cancer treatment

Basic Science ProgramPosted 2/17/2022
Scientists have identified a genetic variant that can predict whether immunotherapy drugs called immune checkpoint inhibitors, used to treat cancer, might fail in certain patients. The team’s findings, which appear in Lancet Oncology, point to HLA-A*03, an allele (a form of a gene) found on chromosome 6 of human DNA. The presence of HLA-A*03 in cancer patients’ DNA was…

Three Frederick National Laboratory teams awarded 2021 NIH director’s awards

Protein Expression Laboratory, Clinical Monitoring Research Program, Terri BrayPosted 2/14/2022
The National Institutes of Health (NIH) awarded three Frederick National Laboratory teams with NIH Director’s Awards for innovative approaches to COVID-19-related research that advances knowledge and enhances health. “It is a tremendous honor for three Frederick National Laboratory teams to be nominated by three distinct entities within NIH. I am grateful to the NIH for…

Women in Science Speak

Partnership Development OfficePosted 2/11/2022
Feb. 11 was International Women and Girls in Science Day. To celebrate, we co-hosted a panel discussion with Woman to Woman Mentoring where successful women in science discussed their chosen career paths, allyship and mentorship in science and strategies for advancement. Keynote speaker Carla Williams, Ph.D. Associate Professor of Medicine &…

Nanotechnology enables potential novel imaging agent for early pancreatic cancer detection

Nanotechnology Characterization Laboratory, Laboratory Animal Sciences ProgramPosted 2/10/2022
Frederick National Laboratory (FNL) scientists, led by Stephan Stern, Ph.D., and their colleagues have created a novel imaging agent that, with further development, might detect deadly pancreatic cancer at its earliest, most-treatable stages and thereby improve the prognosis for patients. Pancreatic cancer has a high mortality rate because it is usually diagnosed late,…

Machine learning-backed model reveals new insights about RAS biology not possible with traditional experiments

RAS InitiativePosted 1/26/2022
A key to understanding KRAS-driven cancers and the role of mutant RAS proteins and to discover new therapeutic possibilities is to better understand how RAS behaves on the cell membrane. Investigating RAS in the context of membranes is somewhat challenging using conventional computational or experimental techniques. In a partnership with researchers from three Department…

Pilot study: PET imaging might improve prostate cancer diagnosis and treatment

Posted 1/24/2022
A pilot study suggests a near real-time method of imaging prostate cancer to aid in organ-sparing treatments, and an innovative as well as accurate way to see whether the cancer has spread. These dual findings stem from research reported in Molecular Imaging and Biology on a relatively new radiotracer used in dynamic positron emission tomography (PET) to detect levels…