Investigators from the Frederick National Laboratory for Cancer Research will share their latest work regarding the use of pre-clinical models for compound screening and tumor characterization,
bioinformatics and technology initiatives, among other topics, at the American Association for Cancer Research 2022 Annual Meeting.
More than 30 abstracts by Frederick National Laboratory investigators will be presented in mini symposia, late-breaking research, poster and National Cancer Institute/National Institutes of Health-sponsored sessions throughout the April 9 – 13 meeting at the Ernest N. Morial Convention Center in New Orleans.
Pre-clinical model presentations
|Complex tumor spheroids, consisting of patient-derived tumor cells and stromal cells (human umbilical vein endothelial cells and mesenchymal cells), serve as a physiologically relevant in vitro model of solid tumors that lends itself to high-throughput screening. Patient-derived organoids are comprised of cultures of patient tumor cells that expand indefinitely and mimic the form and genetic features of the original tumor.
FNL scientists focused on in vitro pharmacology will present studies using the complex spheroid tumor model and patient-derived organoid model. Both models are designed to enable high-throughput screening of drug combinations in pre-clinical studies, in this case of colon and pancreatic cancers and melanoma.
Both models are derived from cell lines from the National Cancer Institute’s Patient-Derived Models Repository, operated for the NCI at the Frederick National Laboratory.
Scientists from the Laboratorys Molecular Characterization Laboratory will present several posters, including one on genomic characterization of patient-derived xenograft models of a diverse set of rare cancers. These models are also from the Patient-Derived Models Repository and serve as a valuable resource for translational researchers interested in preclinical drug development and discovery.
Frederick National Laboratory researchers will participate in the National Cancer Institute’s “Meet the Experts” program held each day at the NCI’s exhibit hall location, booth 1224.
Tommy Turbyville will present, “Studying RAS in Membranes” on Monday, April 11 at 3:30 pm. Yvonne Evrard, operations manager of the Patient-Derived Models Repository, will discuss the resource on Tuesday, April 12 at 10:30 am.
Vladimir Popov, director of the Frederick National Laboratory’s Partnership Development Office, will outline the Laboratory’s resources available to external researchers at an NCI-NIH session on Tuesday, April 12 at 2:30 pm in the convention center’s room 298-299.
Popov and his colleagues will be at booth 3133 in the exhibit hall throughout the event to meet with parties interested in partnering with the Frederick National Laboratory.
Who's Who at the Booth