RAS Initiative Publications

How KRAS Mutations Impair Intrinsic GTP Hydrolysis: Experimental and Computational Investigations.

Song LF, Rabara D*, Bali SK, Pei J, Lau EY, Kirshner D, Lightstone FC, McCormick F, Stephen AG*, Yang Y.

J Chem Inf Model. 2025 Nov 24. doi: 10.1021/acs.jcim.5c02061. Online ahead of print.  PMID: 41284615

Integrating Ultra-Coarse-Grained Protein Models into Accessible Workflows for Multiscale Molecular Dynamics.

Chi BT, Fulcar S, Ipe J, Schleifer O, Subramanian R, Vlases C, Matasci N, Georgouli K, Pottier L, Hsu T, Carpenter TS, Nissley DV*, Lightstone FC, Streitz FH, Ingólfsson HI, Aydin F.

ACS Omega. 2025 Oct 22;10(43):51726-51737. eCollection 2025 Nov 4.  PMID: 41210784

Structural basis for LZTR1 recognition of RAS GTPases for degradation

Dharmaiah S*, Bonsor DA*, Mo SP, Fernandez-Cabrera A, Chan AH*, Messing S*, Drew M*, Vega M, Nissley DV*, Esposito D*, Castel P, Simanshu DK*.

Science. 2025 Sep 11;389(6765):1112-1117. Epub 2025 Sep 11.  PMID: 40934300

An in vitro BRAF activation assay elucidates molecular mechanisms driving disassembly of the autoinhibited BRAF state.

Ritt DA, Durrant DE, Drew MR*, Sandin SI*, Martinez Fiesco JA, Zhang X, Aydin F, Carpenter TS, Scheidemantle GM*, D'Ippolito RA*, Sohn AL*, DeHart CJ*, Shrestha R*, Snead K*, Hull J*, Tempkin JOB, Yang Y, Lightstone FC, Streitz FH, Zhang P, Turbyville TJ*, Stephen AG*, Esposito D*, Ingólfsson HI, Nissley DV*, Morrison DK.

Proc Natl Acad Sci U S A. 2025 Sep 23;122(38):e2508169122. Epub 2025 Sep 15.  PMID: 40953270

Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations

Carpenter TS, Aydin F, Neale C, Van QN*, Zhang X, Bhatia H, Sidabras JW, Frank PH*, Georgouli K, Tempkin JOB, Casamayor VB, Gulten G*, Shrestha R*, Goswami D*, Di Natale F, Chavez JR, Moody A, Moon JY, Oppelstrup T, Glosli JN, Dharuman G, Wong S, Liu S, Hengartner NW, López CA, Nguyen K, Stanley CB, Stanton LG, Patel L, Reddy T, Turbyville TJ*, Van Essen B, Bremer PT, Lightstone FC, Stephen AG*, Gnanakaran S, McCormick F, Nissley DV*, Streitz FH, Ingólfsson HI

Biophys J. S0006-3495(25)00532-6. Aug, 2025: PubMed ID: 40849684

The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling in human papillomavirus type 16-infected cervical cancer cells.

Liu H, Yu L, Majerciak V, Meyer TJ*, Yi M*, Johnson PF, Cam M, Lowy DR, Zheng ZM.

Elife. 2025 Aug 29;13:RP102681. doi: 10.7554/eLife.102681.  PMID: 40878909

Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin 

Terayama K, Furuzono S,Fer N*, Yan W*, Young LC, Czyzyk DJ*, Goldstein de Salazar R, Sasaki M, Uozumi A, Konishi M, Kanda S, Sogawa Y, Yamaguchi M, Tsuji T, Kuroyanagi J, Hayashi M, Ogura Y, Simanshu DK*, Kubota K, Tanaka J, McCormick F

Science 389(6758):402-408. Jul 2025, PubMed ID: 40705882

Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints

Alexander P*, Chan AH*, Rabara D*, Swain M*, Larsen EK*, Dyba M*, Chertov O*, Ashraf M*, Champagne A*, Lin K, Maciag A*, Gillette WK*, Nissley DV*, McCormick F, Simanshu DK*, Stephen AG*

J Biol Chem 110331. Jun 2025, PubMed ID: 40473215

BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction

Simanshu DK*, Xu R, Stice JP, Czyzyk DJ*, Feng S, Denson JP*, Riegler E, Yang Y, Zhang C, Donovan S, Smith BP*, Abreu-Blanco M*, Chen M, Feng C, Fu L, Rabara D*, Young LC, Dyba M*, Yan W*, Lin K, Ghorbanpoorvalukolaie S, Larsen EK*, Malik W, Champagne A*, Parker K, Ju JH, Jeknic S, Esposito D*, Turner DM*, Lightstone FC, Wang B, Wehn PM, Wang K, Stephen AG*, Maciag AE*, Hata AN, Sinkevicius KW, Nissley DV*, Wallace EM, McCormick F, Beltran PJ

Science eadq2004. Jun 2025, PubMed ID: 40504949

Serological surveillance of betacoronaviruses in bat guano collectors: Pre-COVID-19 pandemic and post-SARS-CoV-2 emergence

Ninwattana S, Sterling SL, Rattanatumhi K, Thippamom N, Hirunpatrawong P, Sangsub P, Cheun-Arom T, Esposito D*, Tan CW, Yap WC, Zhu F, Wang LF, Laing ED, Wacharapluesadee S, Putcharoen O

Viruses,17(6), Jun 2025, PubMed ID: 40573428

NMR ¹H, ¹³C, and ¹⁵N resonance assignments of the oncogenic Q61R variant of human NRAS in the active, GTP-bound conformation

Sharma AK*, Tonelli M,Dyba M*, Gillette WK*, Esposito D*, Nissley DV*, McCormick F, Maciag AE*

Biomol NMR Assign, May 2025, PubMed ID: 40316884

Enhanced exploration of protein conformational space through integration of ultracoarse-grained models to multiscale workflows

Aydin F, Georgouli K, Pottier L, Oppelstrup T, Carpenter TS, Tempkin JOB, Bremer PT, Nissley DV*, Streitz FH, Lightstone FC, Ingólfsson HI

J Phys Chem B, May 2025, PubMed ID: 40339149

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine

Maciag AE*, Yang Y, Sharma AK*, Turner DM*, DeHart CJ*, Abdelkarim H, Fan L*, Smith BP*, Kumari V*, Dyba M*, Rigby M*, Castillo Badillo JA*, Adams L, Fornelli L, Fox S*, Brafman A*, Turbyville T*, Gillette W*, Messing S*, Agamasu C*, Wolfe AL, Gysin S, Chan A*, Simanshu D*, Esposito D*, Chertov O*, Stephen AG*, Arkin M,Renslo A, Kelleher NL, Gaponenko V, Lightstone FC, Nissley DV*, McCormick F

Proc Natl Acad Sci USA, 122(19):e2410766122, May 2025, PubMed ID: 40343987

Reversible small molecule multivariant RAS inhibitors display tunable affinity for the active and inactive forms of RAS

Parry CW, Pellicano F, Schüttelkopf AW, Beyer KS, Bower J, Bryson A, Cameron K, Cerutti NM, Clark JP, Davidson SC, Davies K, Drysdale MJ, Engelman J, Estevan-Barber A, Gohlke A, Gray CH, Guthy DA, Hong M*, Hopkins A, Hutchinson LD, Konczal J, Maira M, McArthur D, Mezna M, McKinnon H, Nepravishta R, Ostermann N, Pasquali CC, Pollock K, Pugliese A, Rooney N, Schmiedeberg N, Shaw P, Velez-Vega C, West C, West R, Zecri F, Taylor JB

J Med Chem, Mar 2025, PubMed ID: 40162713

Development of receptor desolvation scoring and covalent sampling in DOCK 6: methods evaluated on a RAS test set

Tan Y*, Chakrabarti M*, Stein RM, Prentis LE, Rizzo RC, Kurtzman T, Fischer M, Balius TE*

J Chem Inf Model, Jan 2025, PubMed ID: 39757424

Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation

Czyzyk D*, Yan W*, Messing S*, Gillette W*, Tsuji T, Yamaguchi M, Furuzono S, Turner DM*, Esposito D*, Nissley DV*, McCormick F, Simanshu DK*

Nat Commun,16(1):525, Jan 2025, PubMed ID: 39788953

The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A

Kochen Rossi J, Nuevo-Tapioles C, O'Keefe RA, Hunkeler M, Schmoker AM, Fissore-O'Leary M, Su W, Ahearn IM, Branco C, Cheong H, Esposito D*, Clotea I, Ueberheide B, Fischer ES, Philips MR.

Cell Rep, 44(1):115087, Dec 2024, PubMed ID: 39705142

Discovery of BBO-8520, a first-in-class direct and covalent dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C

Maciag AE*, Stice JP, Wang B, Sharma AK*, Chan AH*, Lin K, Singh D, Dyba M*, Yang Y, Setoodeh S, Smith BP*, Ju JH, Jeknic S, Rabara D*, Zhang Z, Larsen EK*, Esposito D*, Denson JP*, Ranieri M, Meynardie M, Mehdizadeh S, Alexander PA*, Abreu Blanco M*, Turner DM*, Xu R, Lightstone FC, Wong KK, Stephen AG*, Wang K, Simanshu DK*, Sinkevicius KW, Nissley DV*, Wallace E, McCormick F, Beltran PJ

Cancer Discov, Dec 2024 , PubMed ID: 39642212

The prominent pervasive oncogenic role and tissue-specific permissiveness of RAS gene mutations supported by DepMap high-throughput CRISPR screening data 

Yi M*, Soppet D*, McCormick F, Nissley DV*

Sci Rep,14(1):25452, Oct 2024, PubMed ID: 39455841

Two hearts beat as one: the debate over RAS dimers continues 

Stephen AG*

Trends Biochem Sci, Oct 2024, PubMed ID: 39358051

KRas4b-Calmodulin interaction with membrane surfaces: role of headgroup, acyl chain, and electrostatics 

Shree S, McLean MA, Stephen AG*, Sligar SG

Biochemistry, Oct 2024, PubMed ID: 39382513

Beyond KRAS(G12C): biochemical and computational characterization of sotorasib and adagrasib binding specificity and the critical role of H95 and Y96

Mahran R, Kapp JN, Valtonen S, Champagne A*, Ning J, Gillette W*, Stephen AG*, Hao F, Plückthun A, Härmä H, Pantsar T, Kopra K

ACS Chem Biol, Oct 2024, PubMed ID: 39283696

Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket

Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins ML, Evans JT, Guiley KZ, Peacock DM, Krahnke S*, Lin Z, Taran KA, Huang BJ, Stephen AG*, Burke JE, Lightstone FC, Shokat KM
Cell, Sep 2024, PubMed ID: 39255801

Improved production of class I phosphatidylinositol 4,5-bisphosphate 3-kinase 

Messing S*, Widmeyer SRT*, Denson JP*, Mehalko J*, Wall VE*, Drew M*, Snead K*, Hong M*, Grose C*, Esposito D*, Gillette W*

Protein Expr Purif, 225:106582, Aug 2024, PubMed ID: 39173964

Functional and structural insights into RAS effector proteins

Mozzarelli AM, Simanshu DK*, Castel P 

Mol Cell, Aug 2024, PubMed ID: 39025071

Determining KRAS4B-targeting compound specificity by top-down mass spectrometry 

D'Ippolito RA*, Scheidemantle GM*, Rabara D*, Abreu Blanco M*, Ramakrishnan N*, Widmeyer SRT*, Messing S*, Turner D*, Maciag AE*, Stephen AG*, Esposito D*, McCormick F, Nissley DV*, DeHart CJ*

Methods Mol Biol,2823:291-310, Jul 2024, PubMed ID: 39052227

Natural product graveoline modulates Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) membrane association: insights from advanced spectroscopic studies

Cornilescu G*, Bindu L*, Sternicki L ,Chao FA*, Gillette WK*, Fer N*, Colombus J*, Castillo J*, Andrade Bonilla P*, Van QN*, Larsen E*, Hong M*, Burgan W*, Turbyville T*, Nissley DV*, Liu M, Quinn R, Jean-Francois FL*

ACS Pharmacol Transl Sci,7(7):1983-1995, Jul 2024, PubMed ID: 39022364

KRAS: Methods and Protocols

Stephen AG*, Esposito D*

Methods in Molecular Biology  2024, Springer (Disclaimer)

A top-down proteomic assay to evaluate KRAS4B-compound engagement 

D'Ippolito RA*, Rabara D*, Blanco MA*, Alberico E*, Drew MR*, Ramakrishnan N*, Sontan D*, Widmeyer SRT*, Scheidemantle GM*, Messing S*, Turner D*, Arkin M, Maciag AE*, Stephen AG*, Esposito D*, McCormick F, Nissley DV*, DeHart CJ*

Anal Chem 2024, PubMed ID: 38498381

Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements 

Finci LI*, Chakrabarti M*, Gulten G*, Finney J*, Grose C*, Fox T*, Yang R*, Nissley DV*, McCormick F, Esposito D*, Balius TE*, Simanshu DK* 

Commun Biol,7(1):260 2024, PubMed ID: 38431713

Adapting recombinant bacterial alkaline phosphatase for nucleotide exchange of small GTPases

Frank P*, Hong M*, Higgins B*, Perkins S*, Taylor T*, Wall V*, Drew M*, Waybright T*, Gillette W*, Esposito D*, Messing S* 

Protein Expr Purif 2024, PubMed ID: 38395209

Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by (31)P NMR 

Sharma AK*, Pei J, Yang Y, Dyba M*, Smith B*, Rabara D*, Larsen E*, Lightstone FC, Esposito D*, Stephen AG*, Wang B, Beltran PJ, Wallace E, Nissley DV*, McCormick F, Maciag AE*

J Biol Chem 2024, PubMed ID: 38237681

Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane

Shrestha R*, Carpenter TS, Van QN*, Agamasu C*, Tonelli M, Aydin F, Chen D*, Gulten G*, Glosli JN, López CA, Oppelstrup T, Neale C, Gnanakaran S, Gillette WK*, Ingólfsson HI, Lightstone FC, Stephen AG*, Streitz FH, Nissley DV*, Turbyville TJ*

Commun Biol,7(1):242, 2024, PubMed ID: 38605143

RAS and SHOC2 roles in RAF activation and therapeutic considerations

Bonsor DA*, Simanshu DK*: 

Ann Rev Cancer Bio, 2024, PubMed ID: 38882927

Ras-dependent MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in myocardial hypertrophy 

Cuevas-Navarro A, Wagner M*, Van R, Swain M*, Allison MR, Cheng A, Messing S*, Simanshu DK*,  Sale MJ, McCormick F, Stephen AG, Castel P

Sci Adv,9(28):eadf4766 2023, PubMed ID: 37450595

DOCK 6: Incorporating hierarchical traversal through precomputed ligand conformations to enable large-scale docking

Balius TE*, Tan YS*, Chakrabarti M* 

J Comput Chem 2023, PubMed ID: 37743732

Reduced dynamic complexity allows structure elucidation of an excited state of KRAS(G13D)

Chao FA*, Chan AH*, Dharmaiah S*, Schwieters CD, Tran TH*, Taylor T*, Ramakrishnan N*, Esposito D*, Nissley DV*, McCormick F, Simanshu DK*, Cornilescu G* 

Commun Biol,6(1):594 2023, PubMed ID: 37268708

Machine learning-driven multiscale modeling: bridging the scales with a next-generation simulation infrastructure

Ingólfsson HI, Bhatia H, Aydin F, Oppelstrup T, López CA, Stanton LG, Carpenter TS, Wong S, Di Natale F, Zhang X, Moon JY, Stanley CB, Chavez JR, Nguyen K, Dharuman G, Burns V, Shrestha R*, Goswami D*, Gulten G*, Van QN*, Ramanathan A, Van Essen B, Hengartner NW, Stephen AG*, Turbyville T*, Bremer PT, Gnanakaran S, Glosli JN, Lightstone FC, Nissley DV*, Streitz FH,

J Chem Theory Comput 2023, PubMed ID: 37075065

The Ribosomal S6 Kinase 2 (RSK2)-SPRED2 complex regulates phosphorylation of RSK substrates and MAPK signaling

Lopez J, Bonsor DA*, Sale MJ, Urisman A, Mehalko JL*, Cabanski-Dunning M, Castel P, Simanshu DK*, McCormick F

J Biol Chem 2023, PubMed ID: 37149146

Direct modulators of K-Ras-membrane interactions

Morstein J, Shrestha R*, Van QN*, López CA, Arora N, Tonelli M, Liang H, Chen D*, Zhou Y, Hancock JF, Stephen AG*, Turbyville TJ*, Shokat KM

ACS Chem Biol 2023, PubMed ID: 37579045

GAP positions catalytic H-Ras residue Q61 for GTP hydrolysis in molecular dynamics simulations, complicating chemical rescue of Ras deactivation

Patel LA, Waybright TJ*, Stephen AG*, Neale C

Comput Biol Chem,104:107835 2023, PubMed ID: 36893567

Revealing KRas4b topology on the membrane surface

Shree S, McLean MA, Stephen AG*, Sligar SG

Biochem Biophys Res Commun,678:122-127, 2023, PubMed ID: 37633182

Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties

Whitley MJ*, Tran TH*, Rigby M*, Yi M*, Dharmaiah S*, Waybright TJ*, Ramakrishnan N*, Perkins S*, Taylor T*, Messing S*, Esposito D*, Nissley DV*, McCormick F, Stephen AG*, Turbyville T*, Cornilescu G*, Simanshu DK* 

Sci Adv,10(7):eadj4137, 2023, PubMed ID: 38354232

Allosteric regulation of switch-II domain controls KRAS oncogenicity

Yang MH, Tran TH, Hunt B, Agnor R, Johnson CW, Shui B, Waybright TJ*, Nowak JA, Stephen AG*, Simanshu DK*, Haigis KM

Cancer Res, 2023, PubMed ID: 37556505

Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization

Young LC, Goldstein de Salazar R, Han SW, Huang ZYS, Merk A*, Drew M*, Darling J*, Wall V*, Grisshammer R*, Cheng A, Allison MR, Sale MJ, Nissley DV*, Esposito D*, Ognjenovic J*, McCormick F

Proc Natl Acad Sci U S A,120(5):e2208960120, 2023, PubMed ID: 36689660

The confluence of machine learning and multiscale simulations

Bhatia H, Aydin F, Carpenter TS, Lightstone FC, Bremer PT, Ingólfsson HI, Nissley DV*, Streitz FH

Curr Opin Struct Biol,80:102569, 2023, PubMed ID: 36966691

Structural insights into the role of SHOC2-MRAS-PP1C complex in RAF activation

Bonsor DA*, Simanshu DK* 

FEBS J, 2023, PubMed ID: 37074066

Consensus on the RAS dimerization hypothesis: Strong evidence for lipid-mediated clustering but not for G-domain-mediated interactions

Simanshu DK*, Philips MR, Hancock JF

Mol Cell, 2023, PubMed ID: 36990093

RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation

Spencer-Smith R, Terrell EM, Insinna C, Agamasu C*, Wagner ME*, Ritt DA, Stauffer J, Stephen AG*, Morrison DK

Mol Cell. 2022;82(22):4262-76 e5, PubMed ID: 36347258

Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors

Lai LP*, Fer N*, Burgan W*, Wall V*, Xu B*, Soppet D*, Esposito D*, Nissley DV*, McCormick F

Proc Natl Acad Sci U S A 2022, PubMed ID: 35091470

Insights into the cross talk between effector and allosteric lobes of KRAS from methyl conformational dynamics

Chao FA*, Dharmaiah S*, Taylor T*, Messing S*, Gillette W*, Esposito D*, Nissley DV*, McCormick F, Byrd RA, Simanshu DK*, Cornilescu G*

J Am Chem Soc 2022, PubMed ID: 35213144

Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins

Ingólfsson HI, Neale C, Carpenter TS, Shrestha R*, López CA, Tran TH*, Oppelstrup T, Bhatia H, Stanton LG, Zhang X, Sundram S, Di Natale F, Agarwal A, Dharuman G, Kokkila Schumacher SIL, Turbyville T*, Gulten G*, Van QN*, Goswami D*, Jean-Francois F*, Agamasu C*, Chen D*, Hettige JJ, Travers T, Sarkar S, Surh MP, Yang Y, Moody A, Liu S, Van Essen BC, Voter AF, Ramanathan A, Hengartner NW, Simanshu DK*, Stephen AG*, Bremer PT, Gnanakaran S, Glosli JN, Lightstone FC, McCormick F, Nissley DV*, Streitz FH

Proc Natl Acad Sci USA 2022, PubMed ID: 34983849

The tumor suppressor activity of DLC1 requires the interaction of its START domain with phosphatidylserine, PLCD1, and caveolin-1

Sanchez-Solana B, Wang D, Qian X, Velayoudame P, Simanshu DK*, Acharya JK, Lowy DR

Mol Cancer 2021, PubMed ID: 34727930

NMR 1H,13C, 15N backbone resonance assignments of the T35S and oncogenic T35S/Q61L mutants of human KRAS4b in the active, GppNHp-bound conformation

Sharma AK*, Dyba M*, Tonelli M, Smith B*, Gillette WK*, Esposito D*, Nissley DV*, McCormick F, Maciag AE*

Biomol NMR Assign 2021, PubMed ID: 34686998

Recapitulation of cell-like KRAS4b membrane dynamics on complex biomimetic membranes

Shrestha R*, Chen D*, Frank P*, Nissley DV*, Turbyville TJ*

iScience 2021, PubMed ID: 35106460

Polycistronic baculovirus expression of SUGT1 enables high-yield production of recombinant leucine-rich repeat proteins and protein complexes

Snead K*, Wall V*, Ambrose H*, Esposito D*, Drew M*

Protein Expr Purif 2022, PubMed ID: 35131438

Virtual screening for small-molecule pathway regulators by image-profile matching

Rohban MH, Fuller AM, Tan C, Goldstein JT, Syangtan D, Gutnick A, DeVine A, Nijsure MP, Rigby M, Sacher JR, Corsello SM, Peppler GB, Bogaczynska M, Boghossian A, Ciotti GE, Hands AT, Mekareeya A, Doan M, Gale JP, Derynck R, Turbyville T*, Boerckel JD, Singh S, Kiessling LL, Schwarz TL, Varelas X, Wagner FF, Kafri R, Eisinger-Mathason TSK, Carpenter AE

Cell Syst. 2022;13(9):724-36 e9, PubMed ID: 36057257

RAS at 40: Update from the RAS initiative

Nissley DV*, McCormick F

Cancer Discov 2022, PubMed ID: 35046096

Exploring CRD mobility during RAS/RAF engagement at the membrane

Nguyen K, López CA, Neale C, Van QN*, Carpenter TS, Di Natale F, Travers T, Tran TH*, Chan AH*, Bhatia H, Frank PH, Tonelli M, Zhang X, Gulten G*, Reddy T, Burns V, Oppelstrup T, Hengartner N, Simanshu DK*, Bremer PT, Chen D*, Glosli JN, Shrestha R*, Turbyville T*, Streitz FH, Nissley DV*, Ingólfsson HI, Stephen AG*, Lightstone FC, Gnanakaran S.

Biophys J. 2022;121(19):3630-50, PubMed ID: 35778842

Asynchronous Reciprocal Coupling of Martini 2.2 Coarse-Grained and CHARMM36 All-Atom Simulations in an Automated Multiscale Framework 

López CA, Zhang X, Aydin F, Shrestha R*, Van QN*, Stanley CB, Carpenter TS, Nguyen K, Patel LA, Chen D*, Burns V, Hengartner NW, Reddy TJE, Bhatia H, Di Natale F, Tran TH*, Chan AH*, Simanshu DK*, Nissley DV*, Streitz FH, Stephen AG*, Turbyville TJ*, Lightstone FC, Gnanakaran S, Ingólfsson HI, Neale C

J Chem Theory Comput. 2022;18(8):5025-45, PubMed ID: 35866871

A structure is worth a thousand words: New insights for RAS and RAF regulation

Simanshu DK*, Morrison DK

Cancer Discov 2022, PubMed ID: 35046094

Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome

Bonsor DA*, Alexander P*, Snead K*, Hartig N, Drew M*, Messing S*, Finci LI*, Nissley DV*, McCormick F, Esposito D*, Rodriguez-Viciana P, Stephen AG*, Simanshu DK*

Nat Struct Mol Biol. 2022;29(10):966-77, PubMed ID: 36175670

Mapping the KRAS Proteoform Landscape in Colorectal Cancer Identifies Truncated KRAS4B that Decreases MAPK Signaling

Adams LM, DeHart CJ*, Drown BS, Anderson LC, Bocik W, Boja ES, Hiltke TM, Hendrickson CL, Rodriguez H, Caldwell M, Vafabakhsh R, Kelleher NL  

J Biol Chem. 2022:102768, PubMed ID: 36470426

RAS interaction with Sin1 is dispensable for mTORC2assembly and activity

Castel P, Dharmaiah S*, Sale MJ, Messing S*, Rizzuto G, Cuevas-Navarro A, Cheng A, Trnka MJ, Urisman A, Esposito D*, Simanshu DK*, McCormick F

Proc Natl Acad Sci U S A 2020, PubMed ID: 34380736

Refining the N-termini of the SARS-CoV-2 spike protein and its discrete receptor binding domain

D’Ippolito RA*, Drew MR*, Mehalko J*, Snead K*, Wall V*, Putman Z*, Esposito D*, DeHart CJ*

J Proteome Res 2021, PubMed ID: 34379411

Sensitivity of oncogenic KRAS-expressing cells to CDK9 inhibition

Lai LP*, Brel V, Sharma K*, Frappier J, Le-Henanf N, Vivet B, Muzet N, Schell E, Morales R, Rooney E, Basse N, Yi M*, Lacroix F, Holderfield M*, Englaro W, Marcireau C, Debussche L, Nissley DV*, McCormick F

SLAS Discov 2021, PubMed ID: 33896272

Production and membrane binding of N-terminally acetylated, C-terminally farnesylated and carboxymethylated KRAS4b

Messing S*, Agamasu C*, Drew M*, DeHart CJ*, Stephen AG*, Gillette WK*

Methods Mol Biol 2021, PubMed ID: 33977473

The metabolic landscape of RAS-driven cancers from biology to therapy

Mukhopadhyay S*, Vander Heiden MG, McCormick F*

Nat Cancer 2021, PubMed ID: 33870211

Unveiling the Dynamics of KRAS4b on Lipid Model Membranes

Lopez CA, Agarwal A, Van QN*, Stephen AG*, Gnanakaran S.  

J Membr Biol. 2021;254(2):201-16, PubMed ID: 33825026

Membrane-bound KRAS approximates an entropic ensemble of configurations

Heinrich F, Van QN*, Jean-Francois F*, Stephen AG*, Losche M.

Biophys J. 2021;120(18):4055-66, PubMed ID: 34384763

Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction

Durrant DE, Smith EA, Goncharova EI, Sharma N, Alexander PA*, Stephen AG*, Henrich CJ, Morrison DK

Mol Cancer Ther. 2021;20(9):1743-54, PubMed ID: 34158349

NMR 1H,13C, 15N backbone resonance assignments of the T35S and oncogenic T35S/Q61L mutants of human KRAS4b in the active, GppNHp-bound conformation

Sharma AK*, Dyba M*, Tonelli M, Smith B*, Gillette WK*, Esposito D*, Nissley DV*, McCormick F, Maciag AE*

Biomol NMR Assign 2021, PubMed ID: 34686998

Targeting eIF4A-dependent translation of KRAS signaling molecules

Singh K, Lin J, Lecomte N, Mohan P, Gokce A, Sanghvi VR, Jiang M, Grbovic-Huezo O, Burčul A, Stark SG, Romesser PB, Chang Q, Melchor JP, Beyer RK*, Duggan M, Fukase Y, Yang G, Ouerfelli O, Viale A, de Stanchina E, Stamford AW, Meinke PT, Rätsch G, Leach SD, Ouyang Z, Wendel HG

Cancer Res 2021, PubMed ID: 33632898

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

Tran TH*, Chan AH*, Young LC, Bindu L*, Neale C, Messing S*, Dharmaiah S*, Taylor T*, Denson JP*, Esposito D*, Nissley DV*, Stephen AG*, McCormick F*, Simanshu DK*

Nat Commun 2021, PubMed ID: 33608534

A practical guide to large-scale docking

Bender BJ, Gahbauer S, Luttens A, Lyu J, Webb CM, Stein RM, Fink EA, Balius TE*, Carlsson J, Irwin JJ, Shoichet BK

Nat Protoc 2021, PubMed ID: 34561691

A review of alternative promoters for optimal recombinant protein expression in baculovirus-infected insect cells

Grose C*, Putman Z*, Esposito D*

Protein Expr Purif 2021, PubMed ID: 34087362

RAS nanoclusters: dynamic signaling platforms amenable to therapeutic intervention

Van QN*, Prakash P, Shrestha R*, Balius TE*, Turbyville TJ*, Stephen AG*

Biomolecules 2021, PubMed ID: 33802474

Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane

Van QN*, López CA, Tonelli M, Taylor T*, Niu B, Stanley CB, Bhowmik D, Tran TH*, Frank PH*, Messing S*, Alexander P*, Scott D, Ye X*, Drew M*, Chertov O*, Lösche M, Ramanathan A, Gross ML, Hengartner NW, Westler WM, Markley JL, Simanshu DK*, Nissley DV*, Gillette WK*, Esposito D*, McCormick F*, Gnanakaran S, Heinrich F, Stephen AG*

Proc Natl Acad Sci U S A 2020, PubMed ID: 32913056

Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR

Yan W*, Markegard E, Dharmaiah S*, Urisman A, Drew M*, Esposito D*, Scheffzek K, Nissley DV*, McCormick F*, Simanshu DK*

Cell Rep 2020, PubMed ID: 32697994

Anionic Lipids Impact RAS-Binding Site Accessibility and Membrane Binding Affinity of CRAF RBD-CRD

Travers T, López CA, Agamasu C*, Hettige JJ, Messing S*, García AE, Stephen AG*, Gnanakaran S

Biophys J 2020, PubMed ID: 32649863

ssGSEA score-based Ras dependency indexes derived from gene expression data reveal potential Ras addiction mechanisms with possible clinical implications

Yi M*, Nissley DV*, McCormick F*, Stephens RM*

Sci Rep 2020, PubMed ID: 32581224

RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling

Nelson AC, Turbyville TJ*, Dharmaiah S*, Rigby M*, Yang R, Wang TY, Columbus J*, Stephens R*, Taylor T*, Sciacca D, Onsongo G, Sarver A, Subramanian S, Nissley DV*, Simanshu DK*, Lou E

J Biol Chem 2020, PubMed ID: 32393580

The frequency of Ras mutations in cancer

Prior IA, Hood FE, Hartley JL*

Cancer Res 2020, PubMed ID: 32209560

Homogeneous dual-parametric coupled assay for simultaneous nucleotide exchange and KRAS/RAF-RBD interaction monitoring

Kopra K, Vuorinen E, Abreu-Blanco M*, Wang Q, Eskonen V, Gillette W*, Pulliainen AT, Holderfield M*, Härmä H.

Anal Chem 2020, PubMed ID: 32106676

The small molecule BI-2852 induces a nonfunctional dimer of KRAS.

Tran TH*, Alexander P*, Dharmaiah S*, Agamasu C*, Nissley DV*, McCormick F*, Esposito D*, Simanshu DK*, Stephen AG*, Balius TE*

Proc Natl Acad Sci U S A 2020, PubMed ID: 32047043

Fully Processed Recombinant KRAS4b: Isolating and Characterizing the Farnesylated and Methylated Protein

Agamasu C*, Frank P*, Perkins S*, Waybright T*, Messing S*, Gillette W*, Stephen AG*

J Vis Exp 2020, PubMed ID: 32009649

Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior

Goswami D*, Chen D*, Yang Y, Gudla PR*, Columbus J*, Worthy K*, Rigby M*, Wheeler M*, Mukhopadhyay S*, Powell K*, Burgan W*, Wall V*, Esposito D*, Simanshu D*, Lightstone FC, Nissley DV*, McCormick F*, Turbyville T*
Elife 2020
PubMed ID: 31958057

PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity
Siddiqui FA, Alam C, Rosenqvist P, Ora M, Sabt A, Manoharan GB, Bindu L*, Okutachi S, Catillon M, Taylor T*, Abdelhafez OM, Lönnberg H, Stephen AG*, Papageorgiou AC, Virta P, Abankwa D

ACS Omega 2019, PubMed ID: 31956834

Undermining glutaminolysis bolsters chemotherapy while NRF2 promotes chemoresistance in KRAS-driven pancreatic cancers

Mukhopadhyay S*, Goswami D*, Adiseshaiah PP, Burgan W*, Yi M*, Guerin TM, Kozlov SV, Nissley DV*, McCormick F*

Cancer Res 2020, PubMed ID: 31911550

A Massively Parallel Infrastructure for Adaptive Multiscale Simulations: Modeling RAS Initiation Pathway for Cancer

F. Di Natale, H. Bhatia, T. S. Carpenter, C. Neale, S. Kokkila Schumacher, T. Oppelstrup, L. Stanton, X. Zhang, S. Sundram, T. R. W. Scogland, G. Dharuman, M. P. Surh, Y. Yang, C. Misale, L. Schneidenbach, C. Costa, C. Kim, B. D’Amora, S. Gnanakaran, D. V. Nissley*, F. Streitz, F. C. Lightstone, P.-T. Bremer, J. N. Glosli, H. I. Ingolfsson

SC '19: Proceedings of the International Conference for High Performance Computing, Networking, Storage and Analysis, Article No.: 57, 1–16.
Winner of SC Best Paper Award, DOI: 10.1145/3295500.3356197(Disclaimer)

Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer

Sherekar M*, Han SW, Ghirlando R, Messing S*, Drew M*, Rabara D*, Waybright T*, Juneja P, O'Neill H, Stanley CB, Bhowmik D, Ramanathan A, Subramaniam S, Nissley DV*, Gillette W*, McCormick F*, Esposito D*

J Biol Chem 2019, PubMed ID: 31836666

Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.

Hobbs GA, Baker NM, Miermont AM, Thurman RD, Pierobon M, Tran TH*, Anderson AO, Waters AM, Diehl JN, Papke B, Hodge RG, Klomp JE, Goodwin CM, DeLiberty JM, Wang J, Ng RWS, Gautam P, Bryant KL, Esposito D*, Campbell SL, Petricoin EF, Simanshu DK*, Aguirre AJ, Wolpin BM, Wennerberg K, Rudloff U, Cox AD, Der CJ.

Cancer Discov 2019, PubMed ID: 31649109

AI Meets Exascale Computing: Advancing Cancer Research With Large-Scale High Performance Computing

Bhattacharya T, Brettin T, Doroshow JH, Evrard YA, Greenspan EJ, Gryshuk AL, Hoang TT, Lauzon CBV, Nissley D*, Penberthy L, Stahlberg E, Stevens R, Streitz F, Tourassi G, Xia F, Zaki G

Front Oncol 2019, PubMed ID: 31632915

RIT1 oncoproteins escape LZTR1-mediated proteolysis

Castel P, Cheng A, Cuevas-Navarro A, Everman DB, Papageorge AG, Simanshu DK*, Tankka A, Galeas J, Urisman A, McCormick F.

Science. 2019;363(6432):1226-30, PubMed ID: 30872527

KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis

Rabara D*, Tran TH*, Dharmaiah S*, Stephens RM*, McCormick F*, Simanshu DK*, Holderfield M*

Proc Natl Acad Sci U S A 2019, PubMed ID: 31611389

Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Terrell EM, Durrant DE, Ritt DA, Sealover NE, Sheffels E, Spencer-Smith R, Esposito D*, Zhou Y, Hancock JF, Kortum RL, Morrison DK

Mol Cell 2019, PubMed ID: 31606273

Genome Assembly and Annotation of the Trichoplusia ni Tni-FNL Insect Cell Line Enabled by Long-Read Technologies

Talsania K, Mehta M, Raley C, Kriga Y, Gowda S, Grose C*, Drew M*, Roberts V*, Cheng KT, Burkett S, Oeser S, Stephens R*, Soppet D*, Chen X, Kumar P, German O, Smirnova T, Hautman C, Shetty J, Tran B, Zhao Y, Esposito D*

Genes (Basel). 2019;10(2), PubMed ID: 30678108

Second harmonic generation detection of Ras conformational changes and discovery of a small molecule binder

Donohue E, Khorsand S, Mercado G, Varney KM, Wilder PT, Yu W, MacKerell AD Jr, Alexander P*, Van QN*, Moree B, Stephen AG*, Weber DJ, Salafsky J, McCormick F*

Proc Natl Acad Sci U S A 2019, PubMed ID: 31399543

PIP2 Influences the Conformational Dynamics of Membrane-Bound KRAS4b 

McLean MA, Stephen AG*, Sligar SG

Biochemistry 2019, PubMed ID: 31339036

Organization of Farnesylated, Carboxymethylated KRAS4B on Membranes

Barklis E, Stephen AG*, Staubus AO, Barklis RL, Alfadhli A

J Mol Biol 2019, PubMed ID: 31330153

Structures of N-terminally processed KRAS provide insight into the role of N-acetylation 

Dharmaiah S*, Tran TH*, Messing S*, Agamasu C*, Gillette WK*, Yan W*, Waybright T*, Alexander P*, Esposito D*, Nissley DV*, McCormick F*, Stephen AG*, Simanshu DK*

Sci Rep 2019, PubMed ID: 31324887

Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer

Wang MT, Fer N*, Galeas J, Collisson EA, Kim SE, Sharib J, McCormick F*

Nat Commun 2019, PubMed ID: 31296870

Membrane curvature sensing of the lipid-anchored K-Ras small GTPase

Liang H, Mu H, Jean-Francois F*, Lakshman B*, Sarkar-Banerjee S, Zhuang Y, Zeng  Y, Gao W, Zaske AM, Nissley DV*, Gorfe AA, Zhao W, Zhou Y

Life Sci Alliance 2019, PubMed ID: 31296567

Intercellular Transfer of Oncogenic KRAS via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer Cells

Desir S, Wong P, Turbyville T*, Chen D*, Shetty M, Clark C, Zhai E, Romin Y, Manova-Todorova K, Starr TK, Nissley DV, Steer CJ, Subramanian S, Lou E

Cancers (Basel) 2019, PubMed ID: 31247990

Production of Farnesylated and Methylated Proteins in an Engineered Insect Cell System

Gillette W*, Frank P*, Perkins S*, Drew M*, Grose C*, Esposito D*

Methods Mol Biol 2019, PubMed ID: 31152410

Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors

Bai RY, Esposito D*, Tam AJ, McCormick F*, Riggins GJ, Wade Clapp D, Staedtke V

Gene Ther 2019, PubMed ID: 31127187

New weapons to penetrate the armor: Novel reagents and assays developed at the NCI RAS Initiative to enable discovery of RAS therapeutics

Esposito D*, Stephen AG*, Turbyville TJ*, Holderfield M*

Semin Cancer Biol 2019, PubMed ID: 29432816

KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner

Agamasu C*, Ghirlando R, Taylor T*, Messing S*, Tran TH*, Bindu L*, Tonelli M, Nissley DV*, McCormick F*, Stephen AG*

Biophys Journal 2019, PubMed ID: 30846362

Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane

Lakshman B*, Messing S*, Schmid EM, Clogston JD, Gillette WK*, Esposito D*, Kessing B*, Fletcher DA, Nissley DV*, McCormick F*, Stephen AG*, Jean-Francois FL*

J Biol Chem 2018, PubMed ID: 30559287

GradientScanSurv-An exhaustive association test method for gene expression data with censored survival outcome

Yi M*, Zhu R, Stephens RM*

PloS One 2018, PubMed ID: 30517129

Label-Free Time-Gated Luminescent Detection Method for the Nucleotides with Varying Phosphate Content

Kopra K, Seppälä T, Rabara D*, Abreu-Blanco M*, Kulmala S, HolderfieldM*, Härmä H

Sensors (Basel) 2018, PubMed ID: 30453509

The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling

Biancucci M, Minasov G, Banerjee A, Herrera A, Woida PJ, Kieffer MB, Bindu L*, Abreu-Blanco M*, Anderson WF, Gaponenko V, Stephen AG*, Holderfield M*, Satchell KJF

Sci Signal  2018, PubMed ID: 30279169

Production of authentic geranylgeranylated KRAS4b using an engineered baculovirus system

Procter L*, Grose C*, Esposito D*

Protein Expr Purif 2018, PubMed ID: 29936133

Direct molecular dissection of tumor parenchyma from tumor stroma in tumor xenograft using mass spectrometry-based glycoproteomics

Ye X*, Luke BT, Wei BR, Kaczmarczyk JA, Loncarek J, Dwyer JE, Johann DJ, Saul RG, Nissley DV*, McCormick F*, Whiteley GR*, Blonder J*

Oncotarget 2018, PubMed ID: 29899869

Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain

Travers T, López CA, Van QN*, Neale C, Tonelli M, Stephen AG*, Gnanakaran S

Sci Rep 2018, PubMed ID: 29855542

Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk

Ntai I, Fornelli L, DeHart CJ, Hutton JE, Doubleday PF, LeDuc RD, van Nispen AJ, Fellers RT, Whiteley G*, Boja ES, Rodriguez H, Kelleher NL

Proc Natl Acad Sci USA 2018, PubMed ID: 29610327

Differential Effector Engagement by Oncogenic KRAS

Yuan TL, Amzallag A, Bagni R*, Yi M*, Afghani S, Burgan W*, Fer N*, Strathern LA*, Powell K*, Smith B, Waters AM*, Drubin D, Thomson T, Liao R, Greninger P, Stein GT, Murchie E, Cortez E, Egan RK, Procter L*, Bess M, Cheng KT*, Lee CS, Lee LC, Fellmann C, Stephens R*, Luo J, Lowe SW, Benes CH, McCormick F*

Cell Rep 2018, PubMed ID: 29444439

New weapons to penetrate the armor: Novel reagents and assays developed at the NCI RAS Initiative to enable discovery of RAS therapeutics

Esposito D*, Stephen AG*, Turbyville TJ*, Holderfield M*

Semin Cancer Biol. 2018, PubMed ID: 29432816

Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

Martinko AJ, Truillet C, Julien O, Diaz JE, Horlbeck MA, Whiteley G*, Blonder J*, Weissman JS, Bandyopadhyay S, Evans MJ, Wells JA

Elife 2018, PubMed ID: 29359686

K-Ras4B Remains Monomeric on Membranes over a Wide Range of Surface Densities and Lipid Compositions

Chung JK, Lee YK, Denson JP*, Gillette WK*, Alvarez S, Stephen AG*, Groves JT

Biophys J. 2018, PubMed ID: 29320680

Efforts to Develop KRAS Inhibitors

Holderfield M*

Cold Spring Harb Perspect Med 2018, PubMed ID: 29101115

Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies

Waters AM*, Ozkan-Dagliyan I, Vaseva AV, Fer N*, Strathern LA*, Hobbs GA, Tessier-Cloutier B, Gillette WK*, Bagni R*, Whiteley GR*, Hartley JL*, McCormick F*, Cox AD, Houghton PJ, Huntsman DG, Philips MR, Der CJ

Sci Signal 2018, PubMed ID: 28951536

RAS Proteins and Their Regulators in Human Disease

Simanshu DK*, Nissley DV*, McCormick F*

Cell 2017, PubMed ID: 28666118

Tumor RAS Gene Expression Levels Are Influenced by the Mutational Status of RAS Genes and Both Upstream and Downstream RAS Pathway Genes

Stephens RM*, Yi M*, Kessing B*, Nissley DV*, McCormick F*

Cancer Inform 2017, PubMed ID: 28634423

A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation

Yin G, Kistler S, George SD, Kuhlmann N, Garvey L*, Huynh M, Bagni RK*, Lammers M, Der CJ, Campbell SL

J Biol Chem 2017, PubMed ID: 28154176

RAS signaling: Divide and conquer

Holderfield M*, Morrison DK

Nat Chem Biol 2016, PubMed ID: 27984577

Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface

Ye X, Chan KC, Waters AM*, Bess M, Harned A, Wei BR, Loncarek J, Luke BT, Orsburn BC, Hollinger BD*, Stephens RM*, Bagni R*, Martinko A, Wells JA, Nissley DV*, McCormick F*, Whiteley G*, Blonder J*

Oncotarget 2016, PubMed ID: 27894102

Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

Ritt DA, Abreu-Blanco MT*, Bindu L*, Durrant DE, Zhou M, Specht SI, Stephen AG*, Holderfield M*, Morrison DK

Mol Cell 2016, PubMed ID: 27889448

Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ

Dharmaiah S*, Bindu L*, Tran TH*, Gillette WK*, Frank PH*, Ghirlando R, Nissley DV*, Esposito D*, McCormick F*, Stephen AG*, Simanshu DK*

Proc Natl Acad Sci USA 2016, PubMed ID: 27791178

Single Synonymous Mutations in KRAS Cause Transformed Phenotypes in NIH3T3 Cells

Waters AM*, Bagni R*, Portugal F*, Hartley JL*

PLoS One 2016, PubMed ID: 27684555

Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions

Gillette WK*, Esposito D*, Abreu Blanco M*, Alexander P*, Bindu L*, Bittner C*, Chertov O*, Frank PH*, Grose C*, Jones JE*, Meng Z*, Perkins S*, Van Q, Ghirlando R, Fivash M*, Nissley DV*, McCormick F*, Holderfield M*, Stephen AG*

Sci Rep 2015, PubMed ID: 26522388

Progress in targeting RAF kinases for cancer therapy

Turbyville TJ*, Holderfield M*

Per Med 2015, PubMed ID: 29771643

Dragging RAS back in the ring

Stephen AG*, Esposito D*, Bagni RK*, McCormick F*

Cancer Cell 2014, PubMed ID: 24651010

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