RAS Initiative Postdoctoral Fellow (req2279)

Posted: 11/18/2021
Location: Frederick, MD
Employee Type: exempt full-time
Job ID: req2279


The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.

The primary goal of the NCI RAS Initiative is to discover newtherapeutic interventions against RAS-driven cancers. The NCI RAS Initiative iscomposed of multiple groups focused on protein science,biochemistry/biophysics, structural biology, molecular imaging, computationaland medicinal chemistry, and drug discovery. By understanding the basic biologyof RAS, we aim to identify novel vulnerabilities that allow direct targeting ofthe mutant protein. Specifically, characterizing the interaction of RAS witheffector proteins at the membrane may result in new biological insights. KEY ROLES/RESPONSIBILITIES

  • Perform biophysical measurements to analyze small G-protein- lipid interactions
  • Quantitate the activity of RAS in biological membranes
  • Conduct independent research
  • Analyze data and present research findings to other scientists
  • Stay informed of the latest findings in RAS and membrane biology
  • Submit manuscripts for peer reviewed publication
  • Collaborate with other members of the program or with external institutions


To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of PhD degree in science from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) or eight (8) years relevant experience in lieu of degree. Foreign degrees must be evaluated for U.S. equivalency
  • Expertise with biophysical experiments using artificial lipid bilayers
  • Knowledge of biophysical tools to measure protein - protein and protein - membrane interactions
  • Experience with fluorescence spectroscopy
  • Ability to obtain and maintain a security clearance


Candidates with these desired skills will be given preferential consideration:

  • Demonstrated publication record
  • Experience working on RAS or other small GTPases