Scientist I (req2242)

Posted: 11/3/2021
Location: Frederick, MD
Employee Type: exempt full-time
Job ID: req2242


The AIDS and Cancer Virus Program (ACVP) is an integrated, multidisciplinary program that performs cutting-edge research in an effort to improve our understanding of AIDS-associated disease, including studies intended to facilitate the improved diagnosis, prevention and treatment of HIV infection and AIDS. The Program consists of several research Sections headed by Principal Investigators, whose work spans from fundamental molecular virology through in vitro studies, to in vivo studies in non-human primate (NHP) models. The ACVP also has eight Research Support Core Groups (Cores) that provide critical and often unique technical support capabilities to ACVP laboratories and other laboratories within the NCI and NIH, and to extramural investigators.


The successful Scientist I will join a vibrant and collaborative group under the leadership of Dr. Brandon Keele in the Retroviral Evolution Section within the AIDS and Cancer Virus Program. Our research group utilizes novel approaches and reagents to address questions fundamental to basic HIV biology with an eye to translatability. The key responsibility of the applicant will be to envision, plan, perform, and present study results to the research community at large. We anticipate the successful candidate will contribute to our research portfolio by using one or more of the following model systems: in vitro culture systems, ex plant models, in vivo animal models, and/or computational modeling. The successful applicant will be expected to conduct supervised research in one or more of the following areas:

  • HIV transmission (viral requirements in establishing new infection following mucosal exposure)
  • HIV reservoir dynamics (establishment, persistence, and elimination of the viral reservoir)
  • HIV recombination and immune evasion (mechanisms of viral persistence)
  • Will perform activities to support our efforts to better understand the fundamental aspects of HIV/SIV dynamics, transmission, and virus-host interactions as well as the evolution/immune control of HIV, i.e.: molecular skills including quantitative PCR, molecular cloning of infectious virus, basic CRISPR techniques, virus generation, next generation sequencing and transcriptomics


To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a PhD degree from an accredited college or university according to the Council for Higher Education Accreditation (CHEA) in Virology, Microbiology, Molecular Biology, Immunology, or related field or eight (8) years of related experience. Foreign degrees must be evaluated for U.S. equivalency
  • No experience required beyond the PhD degree
  • Ability to understand and analyze data from complex experimental designs
  • Possess a record of scientific achievements including publication of completed studies and oral or poster presentations at national and international meetings
  • Ability to obtain and maintain a security clearance


Candidates with these desired skills will be given preferential consideration:

  • Cloning and other molecular biology techniques
  • Next-generation sequencing, CRISPR, transcriptomics
  • Basic understanding of HIV biology
  • Excellent oral and written communication skills


  • This position is subject to working with or have potential for exposure to animal(s) and/or animal material(s)
  • This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations