Research Associate II (req2184)

Posted: 10/15/2021
Location: Frederick, MD
Employee Type: exempt full-time
Job ID: req2184


The Frederick National Laboratory for Cancer Research (FNL) is sponsored by the National Cancer Institute (NCI) and operated by the prime contractor Leidos Biomedical Research, Inc. FNL is responsible for pursuing a unique mission in translational and applied biomedical research that is unsuitable for academia, the pharmaceutical industry, or other federal contractors. This open position in Pharmacodynamic Assay Development and Implementation Section (PADIS) is ideally suited for a person who is more interested in applied Research & Development than in pursuing basic research.

The Clinical Pharmacodynamics Biomarkers Program is responsible for identification of biomarkers of response to new targeted agents entering clinical trials in the Developmental Therapeutics Program of the National Cancer Institute. The scope of work includes assay design, development, validation, fitness for purpose testing, transfer of assays to clinical laboratories, and clinical specimen analysis when required. PADIS facilitates mechanistic and performance analysis of putative anti-cancer agents, diagnostic tests, and therapeutic interventions to clinical applications, including distinct molecular signatures for cancer, refined molecular assays, and state-of-the-art imaging techniques that are too high-risk for industry or academia to pursue.


  • Plan and perform experiments, including maintaining cell lines, DNA/RNA/protein analysis, and preparation of cultured cells/organoids for microscopy independently or under supervision
  • Complete literature survey
  • Perform data collection, analysis, and reporting activities. Support data presentation at meetings
  • General laboratory maintenance activities (e.g., organizing and ordering lab supplies, maintaining lab equipment, etc.)


To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of Bachelor's degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) in a field related to biomedical research or four (4) years relevant experience in lieu of degree. Foreign degrees must be evaluated for U.S. equivalency
  • In addition to educational requirements, a minimum of five (5) years related biomedical experience
  • Ability to maintain precise records and to provide detailed data reports to supervisor
  • Experience with advanced imaging instrumentation, software, and technologies
  • Ability to master novel technologies and instrumentation
  • Proficiency with Microsoft Office (Outlook, Excel, Word, and PowerPoint)
  • Ability to obtain and maintain a security clearance


Candidates with these desired skills will be given preferential consideration:

  • Master's degree in biological sciences or biomedical engineering
  • Experience in cell culture, DNA/RNA preparation, basic microscopy as well as protein analysis and quantitation
  • Working knowledge of physicochemical properties of biomaterials, hydrogels and substratum for culturing cells or organoids
  • Proficiency in statistical analysis, literature survey and manuscript writing


  • This position is subject to working with or have potential for exposure to animal(s) and/or animal material(s)
  • This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations