Research Associate I - Molecular Characterization Lab (MoCha) (req2327)

Posted: 12/13/2021
Location: Frederick, MD
Employee Type: exempt full-time
Job ID: req2327

***THE STANDARD WORK HOURS FOR THIS POSITION WILL BE BETWEEN 11AM- 8PM, MONDAY – FRIDAY, HOWEVER REQUIRED HOURS WILL BE VARIABLE AND MAY CHANGEDEPENDING ON LAB REQUIREMENTS. SOME WEEKEND HOURS MAY BE REQUIRED.

PROGRAM DESCRIPTION

The Molecular CharacterizationLaboratory (MoCha) is part of Leidos Biomedical Research's Clinical ResearchDirectorate (CRD) at the Frederick National Laboratory for Cancer Research. TheMoCha Laboratory is responsible for providing high-level research in support ofthe NCI-Cancer Diagnostics Program (CDP) within the Division of CancerTreatment and Diagnosis (DCTD). MoCha is charged with the development andapplication of genomic assays for use in medical research and diagnostics forDCTD-sponsored national extramural clinical trials. The Molecular Characterization Laboratory(MoCha) focuses on development and application of novel genomic assays forclinical applications

KEY ROLES/RESPONSIBILITIES

The Research AssociateI will perform genomic assays (mostly using automated platforms) to facilitate cuttingedge genomic research in support of DCTD projects, e.g., MDNET clinical trials,Patient Derived Xenograft Models (NCI PDMR) project, genomic characterizationof patient samples enrolled in ETCTN/NCLN clinical trials. Responsibilities:

  • Performs nucleic acid extractions, clinical NGS assays, genomics research and/or assay development in collaboration with others for projects
  • Perform next generation sequencing assays
  • Makes detailed observations, analyzes data and interprets results
  • Exercises independent judgment in developing and/or modifying methods and techniques for solving scientific problems
  • Performs molecular assays by adherence to SOPs
  • Maintains essential laboratory supplies and monitors equipment for optimum performance
  • Develops new assays and applies the methods/assays utilizing sound scientific judgement
  • Writes SOPs and performs formal reporting of research data, including presentations and/or scientific publications
  • Maintains knowledge of the most recent literature and scientific presentations relevant to projects
  • May participate in scientific conferences and contribute to scientific journals
  • May be responsible for identifying patentable inventions
  • Will be key staff member for above-mentioned activities
  • Maintains high level of professional expertise through familiarity with scientific literature and presentations
  • Maintains essential laboratory supplies and monitors equipment for optimum performance
  • May participate in scientific conferences and contribute to scientific journals

Thisposition will be located in Frederick, Maryland.

BASIC QUALIFICATIONS

To be considered for this position, you must minimally meetthe knowledge, skills, and abilities listed below:

  • Possession of aBachelor's degree from an accredited college/university according to theCouncil for Higher Education Accreditation (CHEA) or four (4) years ofexperience in lieu of degree. Foreign degrees must be evaluated for U.S. equivalency
  • In addition to education requirements, a minimum of two (2) years of relevant experience
  • Strong technical skills in molecular assays and/or nucleic acid extraction and understanding of QC metrics of nucleic acids
  • Ability to independently evaluate the suitability and quality control of research or production assays or tests, develop and follow SOPs, and analyze and report data
  • Ability to track information in a large cohort of samples and monitor progress of multiple projects
  • Adequate computer skills to document, organize, and present experimental data
  • Strong critical thinking and problem solving skills
  • Ability to communicate effectively, both verbally and in writing
  • Ability to obtain and maintain a security clearance

PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferential consideration:

  • Experience working in a CLIA, CAP, or ISO accredited laboratory
  • Experience in NGS genomic profiling assays (i.e. whole exome sequencing and RNA sequencing), digital PCR
  • Experience in genomic assay development and workflow automation
  • Familiarity with clinical oncology studies and other protocol-driven clinical research
  • Ability to work late afternoons and weekends based on lab work requirements

JOB HAZARDS

  • This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations