Process Development Scientist II (req2321)

Posted: 12/8/2021
Location: Frederick, MD
Employee Type: exempt full-time
Job ID: req2321

PROGRAM DESCRIPTION

TheBiopharmaceutical Development Program (BDP) of Leidos Biomedical Research, Inc.supports the Frederick National Laboratory for Cancer Research (FNLCR) andother government agencies through the development of Cell Therapy products forfirst-in-human clinical studies.

KEY ROLES/RESPONSIBILITIES

  • Cell culture and process development for production of Cell Therapy products
  • Process development and optimization of culture for primary cells (T cell) and product characterization
  • Contribute to the development of robust, high-yielding, and viable cell culture processes for production of CART cells
  • Perform research and clinical scale CAR-T cell production from apheresis to cryopreservation, including aseptic cell culture, selection, transfection, cell counting and flow cytometry
  • DNA transfection, viral transduction, cell characterization, assessing cell function and phenotypic characterization
  • Writing of standard operating procedures, preparing meeting presentations, publication quality drafts and other common laboratory tasks in the field of antibody and protein engineering
  • Evaluate and implement new technologies to support advancement of drug development programs

BASIC QUALIFICATIONS

To beconsidered for this position, you must meet the knowledge, skills, andabilities listed below:

  • Possession of a Doctoral degree related to life sciences from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degree must be evaluated for U.S. equivalency
  • In addition to education requirements, a minimum of two (2) years of hands-on experience with primary cell culture (T cells), mammalian cell culture (CHO, HEK293 etc), and bioreactor process development
  • Experience in cell culture and technology transfer to manufacturing
  • General experience in cell-based assays, transient transfection, assay development and cell characterization
  • Ability to perform data analysis, draw conclusions, and effectively communicate the results to the manager and team
  • Ability to obtain and maintain a security clearance

PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferentialconsideration:

  • Cell culture and bioreactor process development
  • Cell biology and cancer biology and sound technical fundamentals in cell-based assays (e.g. molecular biology, cell culture, flow cytometry, functional assays, etc.)

JOB HAZARDS

  • This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations