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      Vaccine targets

      Scientists report new method for finding a tuberculosis vaccine

      A multi-institutional team used a novel approach for identifying all possible vaccine targets against the disease-causing Mycobacterium tuberculosis.
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      • Vaccine Clinical Materials Program

      Multi-laboratory study demonstrates high agreement among molecular tumor tests

      A study of 26 U.S. laboratories found next-generation sequencing tumor tests produce highly consistent results across different platforms, reinforcing confidence in their reliability for precision cancer care.
    myeloMATCH

    New rapid assay developed to support medicine trial for blood cancers

    Scientists developed a new, precise assay to detect cancer-driving mutations in myeloMATCH precision medicine trials.
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      • Scientific Standards Hub
      Save the date Oct 7-9, 2026

      6th RAS Initiative Symposium

      Join us for the 2026 RAS Initiative Symposium.
    • Innovation
      • Center for Innovation and Strategic Partnerships
      • Patents
      Importance of innovation Within FNL, innovation plays a pivotal role in delivering new and enhanced technologies that empower us to tackle essential scientific inquiries, enhance our services, and ultimately contribute to the wellbeing of patients.
      Vladimir Popov, Ph.D., MBA
    • Scientific Series
      • Biotech Connector
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      • Women in Science Speak
      Hybrid event Feb 19, 2026

      Advancing Drug Development with AI and Computational Science

      Join us for the first Biotech Connector of 2026 discussing the intersection of data science and drug development.
    LZTR1-KRAS affinity

    Exploiting cellular degradation machinery as a potential treatment strategy for RAS-driven cancers

    In a recent study, the Frederick National Laboratory team used the X-ray crystallography technique to reveal the atomic details of how LZTR1 interacts with different RAS family members, including RIT1, MRAS and KRAS.
  • Investigator Resources
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      • BRB Preclinical Biologics Repository
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      SIV/SHIV

      Barcode Analysis Tool

      Download files to demultiplex next-generation sequencing and determine the abundance of individually barcoded SIV/SHIV viral lineages.
    • National Scientific User Facilities
      • Nanotechnology Characterization Laboratory
      • National Cryo-Electron Microscopy Facility
      Assay Cascade Characterization Program

      Next deadline to apply: March 2, 2026

      Preclinical characterization of nanoparticles to facilitate the regulatory review of nanotechnology concepts intended as cancer therapies and diagnostics.
    • Training & Education
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    • Technical Services
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      • HIV/SIV Services
        • Cellular or Tissue SIV/SHIV RNA and DNA testing
        • HIV/SIV Single Genome Amplification and Sequencing
        • Lineage-specific Next Gen Multiplex In Situ Hybridization for HIV or SIV RNA and DNA
        • Next-generation sequencing analysis of barcoded SIV, SHIV, or HIV
        • Novel CD4+ T Cell Specific Immunohistochemistry Detection and Analysis
        • Plasma or CSF SIV/SHIV RNA measurements
        • Quantitative Assessment of Lymphoid Tissue Fibrosis
        • Quantitative assessment of HIV or SIV viral DNA in laser capture microdissected immune cells
        • Viral Integration Site Analysis (VISA) for HIV studies
      • Nanomedicine & Nanoformulation
        • An in vitro drug release study in human plasma
        • Pharmacokinetic study of nanomedicine in rats
      • Other
        • Detection of Mycobacterium tuberculosis DNA
        • TypeSeq2 HPV genotyping services
      Did you know?
      We are home to unique scientific expertise and technological capabilities available nowhere else. The Technical Services Program through the Partnership Development Office makes some of these capabilities and services readily available to the external research community at-cost to advance biomedical research around the world.
    • Universal Standards & Reference Materials
      • AI and Data Science
      • Antibody Science
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      FNL Initiative

      Scientific Standards Hub

      Collection of scientific groups at FNL working to develop, deposit and share standards and references in biological research.
    Training

    FNL Global Clinical Research Educational Modules

    Learn about challenges in clinical research during emergency infectious disease outbreaks and strategies to overcome them.
  • Work With Us
    • Collaboration
      • Partnership Development Office
      • Partnership Mechanisms
      • Academic Partnerships

      Biotech Connector reimagines the future of gene and cell-based therapies

      Frederick’s biotech innovators discussed how they're revolutionizing gene and cell therapies through cutting-edge manufacturing, streamlined supply chains, and powerful automation.
    • Tech Transfer & Licensing
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      Innovation

      FNL Patents

      Technologies invented and patented by researchers at the Frederick National Laboratory
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      solicitation
      Commercial Service
      Due in 2 weeks (03/01/2026)
      Commercial Goods/Services
      X26-172
    Register Your Interest

    Become a Vendor

    Potential vendors seeking to work with us must first complete a New Vendor Registration.
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    Brilliant teamwork The team here is made up of brilliant scientists. Coming from a diverse research background myself, it’s inspiring to be in a room where everyone contributes something unique. I feel truly privileged to be part of it.
    Samarth Mathur, Ph.D.
  • About FNL
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      • People
      • Carissa Grose
      • William Burgan
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    Did you know?
    We are home to unique scientific expertise and technological capabilities available nowhere else. The Technical Services Program through the Partnership Development Office makes some of these capabilities and services readily available to the external research community at-cost to advance biomedical research around the world.

Josh Kramer

Bethesda Attending Veterinarian , Laboratory Animal Medicine
Josh.Kramer@nih.gov
Frederick National Laboratory logo Frederick National Laboratory for Cancer Research is operated by Leidos Biomedical Research, Inc. for the National Cancer Institute.
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  • Research & Technology
    • Science Areas
      • AIDS and Cancer Virus Program
        • Sections
          • Retroviral Evolution Section
          • Retroviral Pathogenesis Section
          • Retrovirus-Cell Interaction Section
          • Viral Oncology Section
          • Viral Persistence Section
        • Cores
          • Biological Products Core
          • Cellular Immunity Core
          • HIV Molecular Monitoring Core
          • Nonhuman Primate Research Support Core
          • Quantitative Molecular Diagnostics Core
          • Tissue Analysis and Retroviral Protein Chemistry Core
          • Viral Evolution Core
      • Basic Science Program
        • Experimental Structural Biology Section
        • Biophysics and Computational Biology Section
        • Epigenetics Section
        • HLA Immunogenetics Section
        • Molecular Immunology Section
      • Bioinformatics and Computational Science
        • Advanced Biomedical Computational Science
        • Center for Technical Operations Support
      • Cancer Research Technology Program
        • Advanced Cryo-Electron Microscopy Technology Group
        • Antibody Characterization Laboratory
        • CLIA Molecular Diagnostics Laboratory
        • Imaging Mass Cytometry Laboratory
        • Molecular Pharmacology Program
        • Protein Expression Laboratory
      • Laboratory Animal Sciences Program
        • Animal Diagnostics Laboratory
        • Animal Research Technical Support
        • Genome Modification Core
        • Gnotobiotics Facility
        • Laboratory Animal Medicine
        • Molecular Histopathology Laboratory
        • Mouse Modeling and Cryopreservation
        • Small Animal Imaging Program
      • Vaccine, Immunity, and Cancer Directorate
        • Cancer Immunoprevention Laboratory
        • HPV Serology Laboratory
    • Clinical Trial Support
      • Applied and Developmental Research Directorate
        • Clinical Services Program
          • AIDS Monitoring Laboratory
          • Bioprocessing Laboratory
          • Blood Processing Core
          • Clinical Support Laboratory
          • Flow Cytometry Support Laboratory
          • Immunological Monitoring Laboratory
          • Laboratory of Human Retrovirology and Immunoinformatics
          • Laboratory of Molecular Cell Biology
          • Neutrophil Monitoring Laboratory
          • Radiochemistry Program
          • Virus Isolation and Serology Laboratory
        • DCTD Support
          • Cancer Imaging Informatics Laboratory
          • Clinical Pharmacodynamics - Biomarkers Program
          • In Vitro Evaluation and Molecular Pharmacology Laboratories
          • In Vivo Evaluation Program
          • Investigative Toxicology Laboratory
          • NExT Chemical Biology Consortium Support Programs
          • Natural Products Support Group
          • Pharmacokinetics and Drug Analysis Group
          • Radiochemistry Support Group
      • Biopharmaceutical Development Program
      • Clinical Monitoring Research Program
      • Clinical Research Directorate
        • Biospecimen Research Group
        • Cancer Genomics Research Laboratory
        • Drug Discovery and Development Program
        • Molecular Characterization Laboratory
      • Vaccine Clinical Materials Program
  • Innovation & Initiatives
    • Initiatives
      • RAS Initiative
        • Biochemistry & Biophysics Research Team
        • Bioinformatics Research Team
        • Chemistry Research Team
        • Computational Chemistry Research Team
        • Drug Screening and Preclinical Research Team
        • Imaging Research Team
        • Mass Spectrometry Research Team
        • Reagents Research Team
        • Structural Biology Research Team
      • Scientific Standards Hub
    • Innovation
      • Center for Innovation and Strategic Partnerships
      • Patents
    • Scientific Series
      • Biotech Connector
      • High Fidelity
      • Life Sciences Symposium
      • RAS Initiative Symposium
      • Scientific Partners Distinguished Lecture Series
      • Technology Showcase
      • Women in Science Speak
  • Investigator Resources
    • All Resources
    • Data & Repositories
      • BRB Preclinical Biologics Repository
      • MHL Immunohistochemistry Database
      • RAS Reagents & Tools
      • dbGuide
      • sgRNA Scorer
      • More Repositories
    • National Scientific User Facilities
      • Nanotechnology Characterization Laboratory
      • National Cryo-Electron Microscopy Facility
    • Training & Education
      • cGMP Training
      • FNL Global Clinical Research Educational Modules
      • Project Management Night Out Seminar Series
    • Technical Services
      • Program Overview
      • HIV/SIV Services
        • Cellular or Tissue SIV/SHIV RNA and DNA testing
        • HIV/SIV Single Genome Amplification and Sequencing
        • Lineage-specific Next Gen Multiplex In Situ Hybridization for HIV or SIV RNA and DNA
        • Next-generation sequencing analysis of barcoded SIV, SHIV, or HIV
        • Novel CD4+ T Cell Specific Immunohistochemistry Detection and Analysis
        • Plasma or CSF SIV/SHIV RNA measurements
        • Quantitative Assessment of Lymphoid Tissue Fibrosis
        • Quantitative assessment of HIV or SIV viral DNA in laser capture microdissected immune cells
        • Viral Integration Site Analysis (VISA) for HIV studies
      • Nanomedicine & Nanoformulation
        • An in vitro drug release study in human plasma
        • Pharmacokinetic study of nanomedicine in rats
      • Other
        • Detection of Mycobacterium tuberculosis DNA
        • TypeSeq2 HPV genotyping services
    • Universal Standards & Reference Materials
      • AI and Data Science
      • Antibody Science
      • Biospecimen Assays
      • Biopharmaceutical Development
      • Electron Microscopy
      • Serology Operating Procedures
      • Human SARS-CoV-2 Serology Standard
      • Nanotechnology
      • Protein Science
  • Work With Us
    • Collaboration
      • Partnership Development Office
      • Partnership Mechanisms
      • Academic Partnerships
    • Tech Transfer & Licensing
      • Intellectual Property and Strategic Agreements
    • Vendors & Subcontractors
      • Become a Vendor
      • Business Opportunities
        • Industrial supplies, biologicals, consumables
      • Contracts and Acquisitions
      • Small Businesses, Nonprofits & HBCUs
  • Careers
    • Job Opportunities
    • Application Process
    • Benefits
    • Internships and Fellowships
  • About
    • Who We Are
    • Mission & Core Values
    • Community Outreach
    • People
      • Carissa Grose
      • William Burgan
    • History
    • Publications