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      Research team identifies possible new targets for liver cancer therapy

      New research may have found a stable population of cells that could serve as a bull's eye for effective liver cancer therapy.
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      Vaccine set for wider use against mosquito-borne chikungunya

      The vaccine Vimkunya may become a bigger player in global health following a series of adverse event reports linked to the only other available vaccine for chikungunya.
    Researcher Resource

    Cancer Moonshot Biobank surpasses 1,000 enrollments

    Exceeding its goal, the Biobank promises to enable cancer research aimed at understanding drug sensitivity and resistance.
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      Save the date Oct 7-9, 2026

      6th RAS Initiative Symposium

      Join us for the 2026 RAS Initiative Symposium.
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      Importance of innovation Within FNL, innovation plays a pivotal role in delivering new and enhanced technologies that empower us to tackle essential scientific inquiries, enhance our services, and ultimately contribute to the wellbeing of patients.
      Vladimir Popov, Ph.D., MBA
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      Life Sciences Symposium Jun 16-18, 2026

      Reproducibility in Science 2026

      Join us for a symposium focused on reproducibility in biomedical research.
    American Association for Cancer Research Annual Meeting

    Preclinical data on potential treatment for RAS-driven cancers to be presented at AACR26

    Studies on BBO-10203 and BBO-11818 will be presented in San Diego.
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      Barcode Analysis Tool

      Download files to demultiplex next-generation sequencing and determine the abundance of individually barcoded SIV/SHIV viral lineages.
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      Assay Cascade Characterization Program

      Next deadline to apply: Sept. 1, 2026

      Preclinical characterization of nanoparticles to facilitate the regulatory review of nanotechnology concepts intended as cancer therapies and diagnostics.
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      Did you know?
      We are home to unique scientific expertise and technological capabilities available nowhere else. The Technical Services Program through the Partnership Development Office makes some of these capabilities and services readily available to the external research community at-cost to advance biomedical research around the world.
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      Collection of scientific groups at FNL working to develop, deposit and share standards and references in biological research.
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    Learn about challenges in clinical research during emergency infectious disease outbreaks and strategies to overcome them.
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      Partnership Spotlight

      Multi-laboratory study demonstrates high agreement among molecular tumor tests

      A study of 26 U.S. laboratories reinforced confidence in next-generation sequencing tumor tests' reliability for precision cancer care.
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      M26-211
    Vendor Webinar Apr 30, 2026

    How to Do Business with Leidos Biomedical Research

    This session will provide a roadmap for navigating the procurement process.
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    Brilliant teamwork The team here is made up of brilliant scientists. Coming from a diverse research background myself, it’s inspiring to be in a room where everyone contributes something unique. I feel truly privileged to be part of it.
    Samarth Mathur, Ph.D.
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    Did you know?
    About 30% of all human cancers are driven by mutations of the RAS family of genes. The RAS Initiative endeavors to better understand the RAS oncogene and discover its vulnerabilities to treat RAS-related cancers.
RAS Initiative

Dhirendra Simanshu

Team Lead, Structural Biology Research Team
dhirendra.simanshu@nih.gov
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News

12/03/2025 Exploiting cellular degradation machinery as a potential treatment strategy for RAS-driven cancers
Frederick National Laboratory logo Frederick National Laboratory for Cancer Research is operated by Leidos Biomedical Research, Inc. for the National Cancer Institute.
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    • Science Areas
      • AIDS and Cancer Virus Program
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        • HIV/SIV Single Genome Amplification and Sequencing
        • Lineage-specific Next Gen Multiplex In Situ Hybridization for HIV or SIV RNA and DNA
        • Next-generation sequencing analysis of barcoded SIV, SHIV, or HIV
        • Novel CD4+ T Cell Specific Immunohistochemistry Detection and Analysis
        • Plasma or CSF SIV/SHIV RNA measurements
        • Quantitative Assessment of Lymphoid Tissue Fibrosis
        • Quantitative assessment of HIV or SIV viral DNA in laser capture microdissected immune cells
        • Viral Integration Site Analysis (VISA) for HIV studies
      • Nanomedicine & Nanoformulation
        • An in vitro drug release study in human plasma
        • Pharmacokinetic study of nanomedicine in rats
      • Other
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        • TypeSeq2 HPV genotyping services
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