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      Tg CLIA assay

      Laboratory develops clinical assay for recurrent thyroid cancer

      CLIA Molecular Diagnostics Laboratory developed and validated a blood test to detect recurrent thyroid cancer following surgical removal of the gland.
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      FNL at ASCO

      ASCO oral presentation, posters to explore use of liquid biopsy in rare cancers

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    KRAS G12C

    RAS drug discovery at Frederick National Laboratory reaches lung cancer patients in a clinical trial

    A first-in-human study seeks to determine the drug’s safety and tolerability and to detect potential antitumor activity.
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      Did you know?
      About 30% of all human cancers are driven by mutations of the RAS family of genes. The RAS Initiative endeavors to better understand the RAS oncogene and discover its vulnerabilities to treat RAS-related cancers.
    • Innovation
      • Center for Innovation and Strategic Partnerships
      • Patents
      Importance of innovation Within FNL, innovation plays a pivotal role in delivering new and enhanced technologies that empower us to tackle essential scientific inquiries, enhance our services, and ultimately contribute to the wellbeing of patients.
      Vladimir Popov, Ph.D., MBA
    • Scientific Series
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      speaker_series Aug 28, 2025

      Biotech Connector: Liquid biopsies

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    BBO-10203

    Drug blocking cancer-driving RAS-PI3K pathway enters clinical trials

    Second drug candidate targeting RAS-related cancers developed by the RAS Initiative, BridgeBio Oncology Therapeutics and Lawrence Livermore National Laboratory.
  • Investigator Resources
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      SIV/SHIV

      Barcode Analysis Tool

      Download files to demultiplex next-generation sequencing and determine the abundance of individually barcoded SIV/SHIV viral lineages.
    • National Scientific User Facilities
      • Nanotechnology Characterization Laboratory
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      Assay Cascade Characterization Program

      Next deadline to apply: Sept. 2, 2025

      Preclinical characterization of nanoparticles to facilitate the regulatory review of nanotechnology concepts intended as cancer therapies and diagnostics.
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        • Cellular or Tissue SIV/SHIV RNA and DNA testing
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        • Quantitative assessment of HIV or SIV viral DNA in laser capture microdissected immune cells
        • Viral Integration Site Analysis (VISA) for HIV studies
      • Laboratory Animal Services
        • Assessment of Drug Efficacy in a Survival Study
        • In Vitro Cell Cytotoxicity Evaluation
        • Pharmacokinetic Evaluation in Kras/p53 PDAC Mice
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        • Use of Mouse Embryonic Stem Cells Expressing miRNAs
      • Nanomedicine & Nanoformulation
        • An in vitro drug release study in human plasma
        • Pharmacokinetic study of nanomedicine in rats
      • Other
        • Detection of Mycobacterium tuberculosis DNA
      Did you know?
      We are home to unique scientific expertise and technological capabilities available nowhere else. The Technical Services Program through the Partnership Development Office makes some of these capabilities and services readily available to the external research community at-cost to advance biomedical research around the world.
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      FNL Initiative

      Scientific Standards Hub

      Collection of scientific groups at FNL working to develop, deposit and share standards and references in biological research.
    New Researcher Resource

    SeroNet study samples available to request

    Investigators can request serological samples from SARS-CoV-2 studies through the SeroNet Study Collections.
  • Work With Us
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      Partnership Spotlight

      National laboratories’ publication wins best paper award

      A review authored by a team spanning LLNL and FNL has been awarded one of two recent Best Paper designations among papers published in Current Opinion in Structural Biology.
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      Innovation

      FNL Patents

      BBO-11818 is now in clinical trials may one day be a targeted treatment for KRAS-driven cancers.
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      • Become a Vendor
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      solicitation
      Scientific Support and Testing Services
      Due in 4 weeks (08/15/2025)
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      X26104
    Register Your Interest

    Become a Vendor

    Potential vendors seeking to work with us must first complete a New Vendor Registration.
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    What do you enjoy about working at the Frederick National Laboratory? I enjoy coming to work every day because of the wonderful team we have.
    Chris Karlovich, Ph.D.
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    Did you know?
    HPV Serology Laboratory helps show single dose of HPV vaccine protects as well as multi-dose.
RAS Initiative

Dhirendra Simanshu

Team Lead, Structural Biology Research Team
dhirendra.simanshu@nih.gov
Portrait photo
Frederick National Laboratory logo Frederick National Laboratory for Cancer Research is operated by Leidos Biomedical Research, Inc. for the National Cancer Institute.
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  • Research & Technology
    • Science Areas
      • AIDS and Cancer Virus Program
        • Sections
          • Retroviral Evolution Section
          • Retroviral Pathogenesis Section
          • Retrovirus-Cell Interaction Section
          • Viral Oncology Section
          • Viral Persistence Section
        • Cores
          • Biological Products Core
          • Cellular Immunity Core
          • HIV Molecular Monitoring Core
          • Nonhuman Primate Research Support Core
          • Quantitative Molecular Diagnostics Core
          • Tissue Analysis and Retroviral Protein Chemistry Core
          • Viral Evolution Core
      • Basic Science Program
        • Computational Structural Biology Section
        • Epigenetics Section
        • HLA Immunogenetics Section
        • Molecular Immunology Section
      • Bioinformatics and Computational Science
        • Advanced Biomedical Computational Science
        • Center for Technical Operations Support
      • Cancer Research Technology Program
        • Advanced Cryo-Electron Microscopy Technology Group
        • Antibody Characterization Laboratory
        • Cancer Data Science Initiatives
        • CLIA Molecular Diagnostics Laboratory
        • Imaging Mass Cytometry Laboratory
        • Protein Expression Laboratory
      • Laboratory Animal Sciences Program
        • Animal Diagnostics Laboratory
        • Animal Research Technical Support
        • Center for Advanced Preclinical Research
        • Genome Modification Core
        • Gnotobiotics Facility
        • Laboratory Animal Medicine
        • Molecular Histopathology Laboratory
        • Mouse Modeling and Cryopreservation
        • Small Animal Imaging Program
      • Vaccine, Immunity, and Cancer Directorate
        • Cancer Immunoprevention Laboratory
        • HPV Serology Laboratory
    • Clinical Trial Support
      • Applied and Developmental Research Directorate
        • Clinical Services Program
          • AIDS Monitoring Laboratory
          • Bioprocessing Laboratory
          • Blood Processing Core
          • Clinical Support Laboratory
          • Flow Cytometry Support Laboratory
          • Immunological Monitoring Laboratory
          • Laboratory of Human Retrovirology and Immunoinformatics
          • Laboratory of Molecular Cell Biology
          • Neutrophil Monitoring Laboratory
          • Radiochemistry Program
          • Virus Isolation and Serology Laboratory
        • DCTD Support
          • Cancer Imaging Informatics Laboratory
          • Clinical Pharmacodynamics - Biomarkers Program
          • In Vitro Evaluation and Molecular Pharmacology Laboratories
          • In Vivo Evaluation Program
          • Investigative Toxicology Laboratory
          • NExT Chemical Biology Consortium Support Programs
          • Natural Products Support Group
          • Pharmacokinetics and Drug Analysis Group
          • Radiochemistry Support Group
      • Biopharmaceutical Development Program
      • Clinical Monitoring Research Program
      • Clinical Research Directorate
        • Biospecimen Research Group
        • Cancer Genomics Research Laboratory
        • Drug Discovery and Development Program
        • Molecular Characterization Laboratory
      • Vaccine Clinical Materials Program
  • Innovation & Initiatives
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        • Reagents Research Team
        • Structural Biology Research Team
      • Scientific Standards Hub
    • Innovation
      • Center for Innovation and Strategic Partnerships
      • Patents
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