FNLCR laboratories are equipped with the most sophisticated next generation sequencing technology including Illumina,
Life Technologies, Roche 454 and Pacific Biosciences instruments. FNLCR staff are highly trained in library construction
techniques and can handle the most challenging sequencing projects. FNLCR is equipped with the computational storage,
processors and bioinformatics staff to analyze and deliver results for any sequencing project with particular
expertise n combinig seqeunce results from multiple platforms.
Modifications in DNA and chromatin can have a profound effect within cellular systems. The FNLCR has strong capabilities
in the detection of epigentic modifications including ChIP-Seq on the Illumina platforms, Single Molecule detection
of base modifications on the PacBio sequencer and targeed quantitative measurements using the Qiagen Pyromark
Alterations in DNA structure as a result of DNA rearrangements, Viral integration or transgenic manipulation
can have a profound effect on cellular phenotype. The FNLCR has capabilities to evalaute structural alterations
using both Array and Next generation sequencing approaches.
The FNLCR has outstanding facilities for measuring gene expression differences that may be used in both basic and
translational science. Capabilities include a full range of Affymetrix single cartridge and high throughput arrays,
RNA-Seq protocols,Agilent custom arrays, and microfluidic real time PCR. Scientists within the laboratory are
avaialble to consult on project design and to participate in the interpretation of experimental results.
Technical advances now allow measurements of DNA and RNA on single tumor cells. The FNLCR has capablites to make
single cell gene expression measurements and will be establishing single cell genomic sequencing in the latter
half of 2013
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