Is an integrated, high-throughput molecular biology laboratory focusing on the development
of genetics and genomics technologies, together with associated laboratory automation
systems, data analysis, and information management tools. The laboratory develops
integrated strategies using multiple technology platforms that maximize the value
of clinical samples and lead to the identification of pathways, genes, or gene products
involved in the development of disease, as well as the assembly of genetic or expression
profiles for the identification of prognostic and diagnostic indicators.
Expression arrays: A large variety of services to measure gene
expression and DNA copy number variations are available from the LMT. We deliver
Affymetrix services that include single arrays and high throughput formats. We provide
array-based comparative genomic hybridization on Agilent microarray platforms. Measurement
of expression for focused gene sets and miRNA can be carried out on the Nanostring
MolecularDiagnostics: Sanger sequencing-based mutation detection
services in a CLIA environment for investigators evaluating patients for specific
genetic abnormalities. We have established a large panel of mutation detection assays
and will develop new assays on request.
Genotyping and Quantitative PCR: The laboratory has considerable
experience with many assays using ABI’s TaqMan chemistry from copy number variation
assays to SNP assays to quantitative PCR assays. The Fluidigm microfluidics platform
is a great choice for projects requiring large numbers of gene expression measurements
as well as customized assay design for all types of qPCR assays.
Providing high-throughput sequencing technologies to identify single nucleotide
polymorphisms, insertions and deletions, and copy number or structural variations.
Researchers are provided access to the latest technologies, Illumina, SOLiD, PacBio
RS, SOLiD , IonTorrent and Roche/454, with variety of options for NGS library preparations,
consultation and Q&A services available throughout the design and execution of sequencing
projects. There is also a customized assay design for all types of qPCR assays.
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