Paving the Way for Biomedical Innovation

The Frederick National Laboratory meets the nation’s most urgent biomedical research needs and serves as a national and global resource for the scientific community. 

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Cancer Research

AACR25

Drugs targeting KRAS cancers co-developed by FNL to be featured at AACR Annual Meeting 

Study results of two investigational drugs that target KRAS-driven cancers co-developed by RAS Initiative investigators at...

One shot of HPV vaccine protects long-term against cervical cancer

Women should be safe from cancer-causing human papilloma virus (HPV) for at least 20 years and probably more after just one...

Different high-risk HPV infections don’t spur cancers at the same rate

A study mapped the frequency at which different high-risk human papillomavirus (HPV) strains progress to cervical cancer and...

Simulations implicate structural changes as a culprit in mutant protein’s cancer role and point to possible treatments

As Ruth Nussinov , Ph.D., and her team watched a mutated, cancer-causing protein twist and bend across their computer screen...

Drug blocking cancer-driving RAS-PI3K pathway enters clinical trials

A new investigational drug co-developed by Frederick National Laboratory for Cancer Research (FNL) scientists blocks an...

FNL clinical research professionals help boost enrollment, productivity for NCI-sponsored clinical trials via novel virtual initiative

Virtual support from Frederick National Laboratory for Cancer Research (FNL) clinical research professionals helps on-site...

Partnership Spotlight

National laboratories’ publication wins best paper award

A review authored by a team spanning Lawrence Livermore National Laboratory (LLNL) and Frederick National Laboratory for...
What is this?

Image of a distal mouse femur with mineralization scored via random forest classification using HALO image analysis software. The Molecular Histopathology Laboratory investigates treatments for cancer and infectious diseases within the Laboratory Animal Sciences Program by providing support for tissue-based research in understanding disease mechanisms, integrating research and diagnostic activities, and characterizing multiple mouse models of cancer.
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Initiative

RAS Initiative

Discovering the Secrets of a Prevalent Oncogene
The RAS Initiative mobilizes the cancer research community to develop ways to treat cancers driven by the mutant RAS gene in an open model of collaboration among government, academic, and industry researchers.
Discover RAS Science
220,000
People per year in the U.S. are diagnosed with cancers caused by KRAS mutations.
What is this? Surface representation of the structure of an oncogenic mutant of KRAS in complex with RAS-binding domains of RAF1 Kinase. The GMPPNP bound to oncogenic KRAS mutant is shown in ball-and-stick representation.
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Initiative

Scientific Standards Hub

Bridging gaps in scientific reproducibility
Our scientists establish standards and reference reagents for diverse scientific  disciplines and  encourage the adoption of benchmarks  among researchers. 
Visit the Hub
8
disciplines with tools to help bridge gaps in scientific reproducibility.

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Work with the best of the best biomedical researchers and investigators. Be a part of groundbreaking solutions that benefit public health throughout the world. And, enjoy some of the best benefits in the region. We are looking for smart, passionate problem solvers for benchwork, data science, manufacturing, and more.

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