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HIV/AIDS Research

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Scientists and clinicians whose discoveries have shaped the understanding of HIV disease will provide updates on the status of HIV/AIDS research and patient care and discuss approaches to overcome major remaining challenges at a scientific symposium hosted by Hood College in partnership with the Frederick National Laboratory for Cancer Research (…
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HIV ravages the immune system in people who acquire it, but not everyone is affected equally. In some of these individuals, the effects of the virus don’t manifest as swiftly as in others. Scientists have long recognized that people’s genes and the proteins they encode play a role in why this is. Now, a team in Frederick National Laboratory’s…
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Research led by the Frederick National Laboratory for Cancer Research (FNL) and Gilead Sciences shows the potential for a new drug that might only need to be taken twice a year to prevent HIV infection. The drug manufacturer is planning a clinical trial.  The drug, Lenacapavir, recently approved by the Food and Drug Administration as a…
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A years-long case study has potentially identified another factor with which HIV treatment efforts must contend: Inflammation could be a linchpin in the virus’ overexpression in some people. The findings come from the treatment of a person living with HIV. The study, led by the HIV Dynamics and Replication Program at the National Cancer…
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People with HIV on long-term antiretroviral therapy show signs of brain damage and cognitive impairment on a battery of imaging, laboratory, and functional tests, and they report a greater degree of difficulty with the routine tasks of everyday life, according to a new study. The study, published in April in the journal Neurology, is the first…
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Each year, the Frederick National Laboratory offers its scientists an opportunity to compete for funding to conduct the research they view as critical to advance biomedical research but is outside the scope of their daily research activities. This year, three proposals earned funding through the program, known as the Laboratory Directed…
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Five new projects led by Frederick National Laboratory for Cancer Research (FNL) scientists have earned Laboratory Directed Exploratory Research (LDER) funding for the upcoming fiscal year. The LDER program, which was modeled after the U.S. Department of Energy’s Laboratory Directed Research and Development program, provides FNL scientists…
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Frederick National Laboratory scientists were part of a multi-institutional collaboration that has identified a second patient whose natural immune response to HIV infection appears to have cured her of the disease, raising the question: Can this be replicated? Only three other patients have ever been declared fully cured, but each of these…
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HIV plays a direct role in causing blood cell cancers in rare instances, says a new study of HIV and tumor DNA. Scientists have long known that HIV contributes to several cancers by weakening the immune system’s ability to fend off cancer-causing infections like Kaposi sarcoma–associated herpesvirus and Epstein-Barr virus. However, this latest…
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The Frederick National Laboratory for Cancer Research (FNL) not only tackles some of the world’s greatest biomedical challenges but also serves as a shared national resource to enable high-quality research beyond its walls. One way FNL does this is through the Technical Services Program. The Technical Services Program gives investigators…